ArticleCritical care medicine2018
The Association of Nutrition Status Expressed as Body Mass Index z Score With Outcomes in Children With Severe Sepsis: A Secondary Analysis From the Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study.
Article in Critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Is Undernutrition Associated With Deterioration of Outcomes in the Pediatric Intensive Care Unit (PICU): Systematic and Meta-Analysis Review.Frontiers in pediatrics · 2022Pooled it
- Time-critical sepsis interventions and clinical outcomes among children in a tertiary Tanzanian emergency department.BMC pediatrics · 2026Article
- Feeding or Failing? Rethinking Nutrition Therapy in Pediatric Critical Care.Current nutrition reports · 2026Review
- Comparative Prognostic Accuracy of Objective Nutritional Indices in Critically Ill Patients with Sepsis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Early Body Mass Index Trajectory as a Marker of Metabolic and Nutritional Changes in Critically Ill Patients.Nutrients · 2026Article
- Obesity as a Risk Factor in Pediatric Sepsis: A Retrospective Comparative Study Under the Phoenix Definition.Journal of clinical medicine · 2025Article
- Height status matters for risk of mortality in critically ill children.Journal of intensive care · 2024Article
- Personalized Nutrition in the Pediatric ICU: Steering the Shift from Acute Stress to Metabolic Recovery and Rehabilitation.Nutrients · 2024Review
- Post-discharge complications and hospital readmissions are associated with nutritional risk and malnutrition status in a cohort of Canadian pediatric patients.BMC pediatrics · 2024Article
- Viral DNAemia and DNA Virus Seropositivity and Mortality in Pediatric Sepsis.JAMA network open · 2024Article
- The Clinical Impact of Metagenomic Next-Generation Sequencing (mNGS) Test in Hospitalized Patients with Suspected Sepsis: A Multicenter Prospective Study.Diagnostics (Basel, Switzerland) · 2023Article
- Nucleated red blood cells as a novel biomarker in the diagnosis and prediction of sepsis severity in children.Frontiers in cellular and infection microbiology · 2023Article
- PN Administration in Critically Ill Children in Different Phases of the Stress Response.Nutrients · 2022Review
- Growth Failure Prevalence in Neonates with Gastroschisis : A Statewide Cohort Study.The Journal of pediatrics · 2021Article
- Clinical and microbiological characterization of sepsis and evaluation of sepsis scores.PloS one · 2021Observational
- Undernutrition and Obesity Are Associated with Adverse Clinical Outcomes in Hospitalized Children and Adolescents with Acute Pancreatitis.Nutrients · 2020Article
- Combination of serum lactate dehydrogenase and sex is predictive of severe disease in patients with COVID-19.Medicine · 2020Observational
- The impact of body mass index on resource utilization and outcomes of children admitted to a pediatric intensive care unit.SAGE open medicine · 2019Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesThe impact of nutrition status on outcomes in pediatric severe sepsis is unclear. We studied the association of nutrition status (expressed as body mass index z score) with outcomes in pediatric severe sepsis.
designSecondary analysis of the Sepsis Prevalence, Outcomes, and Therapies study. Patient characteristics, ICU interventions, and outcomes were compared across nutrition status categories (expressed as age- and sex-adjusted body mass index z scores using World Health Organization standards). Multivariable regression models were developed to determine adjusted differences in all-cause ICU mortality and ICU length of stay by nutrition status.
settingOne-hundred twenty-eight PICUs across 26 countries. PATIENTS: Children less than 18 years with severe sepsis enrolled in the Sepsis Prevalence, Outcomes, and Therapies study (n = 567).
interventionsNone. MEASUREMENTS AND MAIN
resultsNutrition status data were available for 417 patients. Severe undernutrition was seen in Europe (25%), Asia (20%), South Africa (17%), and South America (10%), with severe overnutrition seen in Australia/New Zealand (17%) and North America (14%). Severe undernutrition was independently associated with all-cause ICU mortality (adjusted odds ratio, 3.0; 95% CI, 1.2-7.7; p = 0.02), whereas severe overnutrition in survivors was independently associated with longer ICU length of stay (1.6 d; p = 0.01).
conclusionsThere is considerable variation in nutrition status for children with severe sepsis treated across this selected network of PICUs from different geographic regions. Severe undernutrition was independently associated with higher all-cause ICU mortality in children with severe sepsis. Severe overnutrition was independently associated with greater ICU length of stay in childhood survivors of severe sepsis.
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