Evidence map›Paper›PMID 30095162›Full record

ArticleInternational journal of cancer2018

An overview of 25 years of incidence, treatment and outcome of colorectal cancer patients.

Nelleke P M Brouwer, Amanda C R K Bos, Valery E P P Lemmens, Pieter J Tanis, Niek Hugen, Iris D Nagtegaal, Johannes H W de Wilt, Rob H A Verhoeven

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 13 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 13 syntheses or guidelines pooled it, 302 citations in OpenAlex.

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  10. Impact of SARS-CoV-2 Pandemic on Colorectal Cancer Screening Delay: Effect on Stage Shift and Increased Mortality.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021
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  17. Health-related quality of life and functional outcomes of colon cancer patients in the Netherlands: A population-based study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
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91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Nelleke P M BrouwerDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-2268-9668
Amanda C R K BosDepartment of Research, Netherlands Comprehensive Cancer Organization (NCR), Utrecht, The Netherlands.
Valery E P P LemmensDepartment of Research, Netherlands Comprehensive Cancer Organization (NCR), Utrecht, The Netherlands.
Pieter J TanisDepartment of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
Niek HugenDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Iris D NagtegaalDepartment of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
Johannes H W de WiltDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Rob H A VerhoevenDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Radboud University Nijmegen · NLAmsterdam UMC Location University of Amsterdam · NLErasmus MC · NLNetherlands Comprehensive Cancer Organisation · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regarding the continuous changes in the diagnostic process and treatment of colorectal cancer (CRC), it is important to evaluate long-term trends which are relevant in giving direction for further research and innovations in cancer patient care. The aim of this study was to analyze developments in incidence, treatment and survival for patients diagnosed with CRC in the Netherlands. For this population-based retrospective cohort study, all patients diagnosed with CRC between 1989 and 2014 in the Netherlands were identified using data of the nationwide population-based Netherlands Cancer Registry (n = 267,765), with follow-up until January 1, 2016. Analyses were performed for trends in incidence, mortality, stage distribution, treatment and relative survival measured from the time of diagnosis. The incidence of both colon and rectal cancer has risen. The use of postoperative chemotherapy for Stage III colon cancer increased (14-60%), as well as the use of preoperative (chemo)radiotherapy for rectal cancer (2-66%). The administration of systemic therapy and metastasectomy increased for Stage IV disease patients. The 5-year relative survival increased significantly from 53 to 62% for colon cancer and from 51 to 65% for rectal cancer. Ongoing advancements in treatment, and also improvement in other factors in the care of CRC patients-such as diagnostics, dedicated surgery and pre- and postoperative care-lead to a continuous improvement in the relative survival of CRC patients. The increasing incidence of CRC favors the implementation of the screening program, of which the effects should be monitored closely.

Indexed as

AdolescentAdultAgedAged, 80 and overChildChild, PreschoolColorectal NeoplasmsFemaleHumansIncidenceInfantInfant, NewbornMaleMiddle AgedNeoplasm StagingNetherlandscolon cancercolorectal cancerepidemiologyincidencemortalityrectal cancerstage distributionsurvivaltreatmenttrends

Identifiers

PMID30095162
PMCPMC6282554
OpenAlexW2887683450

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.