Evidence map›Paper›PMID 30095083›Full record

ArticlePhysics in medicine and biology2018

Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static

Qing Ye, Jing Wu, Yihuan Lu, Mika Naganawa, Jean-Dominique Gallezot, Tianyu Ma, Yaqiang Liu, Lynn Tanoue, Frank Detterbeck, Justin Blasberg and 4 more

Registry-linked trialAbstract read
In one paragraph

Article in Physics in medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05374564 (Parametric Cardiac 18F-flutemetamol PET Imaging in ATTR Cardiomyopathy), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05374564 phase1completednot on this mapstarted 2022, after this paper: background citation

Parametric Cardiac 18F-flutemetamol PET Imaging in ATTR Cardiomyopathy

TypeinterventionalSponsorYale UniversityRan2022 to 2024Enrolled12ConditionsCardiomyopathies, PrimaryArms(18F)Flutemetamol
3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Self-supervised neural network for Patlak-based parametric imaging in dynamic [European journal of nuclear medicine and molecular imaging · 2025
    Article
  4. A deep learning method for total-body dynamic PET imaging with dual-time-window protocols.European journal of nuclear medicine and molecular imaging · 2025
    Article
  5. Article
  6. Article
  7. Diagnostic Performance of Dynamic Whole-Body Patlak [Journal of clinical medicine · 2023
    Article
  8. Generation of Whole-Body FDG ParametricIEEE transactions on radiation and plasma medical sciences · 2023
    Article
  9. Article
  10. Inter-pass motion correction for whole-body dynamic PET and parametric imaging.IEEE transactions on radiation and plasma medical sciences · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qing YeDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States of America.ORCID 0000-0003-2055-218X
Jing WuDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States of America.
Yihuan LuDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States of America.
Mika NaganawaDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States of America.
Jean-Dominique GallezotDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States of America.
Tianyu MaDepartment of Engineering Physics, Tsinghua University, Beijing, People's Republic of China.
Yaqiang LiuDepartment of Engineering Physics, Tsinghua University, Beijing, People's Republic of China.
Lynn TanoueDepartment of Internal Medicine, Yale Lung Screening and Nodule Program, Yale University, New Haven, CT, United States of America.
Frank DetterbeckThoracic Oncology Program, Yale Cancer Center, Yale University, New Haven, CT, United States of America.
Justin BlasbergThoracic Oncology Program, Yale Cancer Center, Yale University, New Haven, CT, United States of America.
Ming-Kai ChenDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States of America.
Michael CaseyMolecular Imaging, Siemens Medical Solutions USA, Inc., Malvern, PA, United States of America.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States of America.
Chi LiuDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States of America.

Funding

Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
Quantitative Low-Dose PET ImagingR01EB025468 · NIBIB · YALE UNIVERSITY · PI CARSON, RICHARD E., LIU, CHI · 2018 to 2022
$3.2M
State-of-the-Art Small Animal PET/CT InstrumentationS10OD010322 · OD · YALE UNIVERSITY · PI CARSON, RICHARD E. · 2013 to 2013
$595k
NCATS NIH HHS UL1 TR000142NIBIB NIH HHS R01 EB025468NIH HHS S10 OD010322
6 · The paper itself

Abstract

Lung cancer mortality rate can be significantly reduced by up to 20% through routine low-dose computed tomography (LDCT) screening, which, however, has high sensitivity but low specificity, resulting in a high rate of false-positive nodules. Combining PET with CT may provide more accurate diagnosis for indeterminate screening-detected nodules. In this work, we investigated low-dose dynamic

Indexed as

AlgorithmsAgedAged, 80 and overFemaleFluorodeoxyglucose F18HumansLung NeoplasmsMaleMiddle AgedPositron-Emission TomographyRadiation DosageRadiopharmaceuticalsROC CurveSolitary Pulmonary NoduleFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

PMID30095083
PMCPMC6158045

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.