ArticleeLife2018
A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Revisiting MAC as a static measure of anaesthesia: evidence for dynamic responses under isoflurane in male mice.British journal of anaesthesia · 2026Article
- Early reactivation of medial temporal lobe neurons during emergence from propofol anesthesia in neurosurgical patients.bioRxiv : the preprint server for biology · 2026Article
- An experimental study of the effect of neuromuscular blockade on EEG-based measures of awareness.Scientific reports · 2026Article
- The Modulatory Effects of Anesthetics and Analgesics on Neurophysiological Monitoring and Underlying Mechanisms.Current neuropharmacology · 2026Review
- Solving the enigma of burst suppression.British journal of anaesthesia · 2025Article
- Brain state identification and neuromodulation to promote recovery of consciousness.Brain communications · 2024Review
- Diversity of electroencephalographic patterns during propofol-induced burst suppression.Frontiers in systems neuroscience · 2023Article
- Deep neural networks constrained by neural mass models improve electrophysiological source imaging of spatiotemporal brain dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Automated intraoperative central sulcus localization and somatotopic mapping using median nerve stimulation.Journal of neural engineering · 2022Article
- Biophysical Model: A Promising Method in the Study of the Mechanism of Propofol: A Narrative Review.Computational intelligence and neuroscience · 2022Review
- Article
- Electroencephalographic Evidence for Individual Neural Inertia in Mice That Decreases With Time.Frontiers in systems neuroscience · 2021Article
- A soft and stretchable bilayer electrode array with independent functional layers for the next generation of brain machine interfaces.Journal of neural engineering · 2020Article
- Birhythmic Analog Circuit Maze: A Nonlinear Neurostimulation Testbed.Entropy (Basel, Switzerland) · 2020Article
- Decoding the circuitry of consciousness: From local microcircuits to brain-scale networks.Network neuroscience (Cambridge, Mass.) · 2020Review
- Electroencephalography: Clinical Applications During the Perioperative Period.Frontiers in medicine · 2020Review
- General Anesthesia: A Probe to Explore Consciousness.Frontiers in systems neuroscience · 2019Article
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Authors and funding
11 authors.
Funding
Abstract
During awake consciousness, the brain intrinsically maintains a dynamical state in which it can coordinate complex responses to sensory input. How the brain reaches this state spontaneously is not known. General anesthesia provides a unique opportunity to examine how the human brain recovers its functional capabilities after profound unconsciousness. We used intracranial electrocorticography and scalp EEG in humans to track neural dynamics during emergence from propofol general anesthesia. We identify a distinct transient brain state that occurs immediately prior to recovery of behavioral responsiveness. This state is characterized by large, spatially distributed, slow sensory-evoked potentials that resemble the K-complexes that are hallmarks of stage two sleep. However, the ongoing spontaneous dynamics in this transitional state differ from sleep. These results identify an asymmetry in the neurophysiology of induction and emergence, as the emerging brain can enter a state with a sleep-like sensory blockade before regaining responsivity to arousing stimuli.
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