ArticleCell transplantation2018
An Ex Vivo Vessel Injury Model to Study Remodeling.
Article in Cell transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Article
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- Perfusion Bioreactor Conditioning of Small-diameter Plant-based Vascular Grafts.Tissue engineering and regenerative medicine · 2024Article
- Exploring the Potential of Saphenous Vein Grafts Ex Vivo: A Model for Intimal Hyperplasia and Re-Endothelialization.Journal of clinical medicine · 2024Article
- Synergistic coupling between 3D bioprinting and vascularization strategies.Biofabrication · 2023Review
- Engineering Smooth Muscle to Understand Extracellular Matrix Remodeling and Vascular Disease.Bioengineering (Basel, Switzerland) · 2022Review
- 3D Printed Bioreactor Enabling the Pulsatile Culture of Native and Angioplastied Large Arteries.Frontiers in cardiovascular medicine · 2022Article
- 3D Tissue-Engineered Vascular Drug Screening Platforms: Promise and Considerations.Frontiers in cardiovascular medicine · 2022Review
- Application of decellularized vascular matrix in small-diameter vascular grafts.Frontiers in bioengineering and biotechnology · 2022Review
- An ex vivo physiologic and hyperplastic vessel culture model to study intra-arterial stent therapies.Biomaterials · 2021Article
- Vascular Tissue Engineering: Challenges and Requirements for an Ideal Large Scale Blood Vessel.Frontiers in bioengineering and biotechnology · 2021Review
- Efficient Differentiation of Human Induced Pluripotent Stem Cells into Endothelial Cells under Xenogeneic-free Conditions for Vascular Tissue Engineering.Acta biomaterialia · 2021Article
- Toward the Effective Bioengineering of a Pathological Tissue for Cardiovascular Disease Modeling: Old Strategies and New Frontiers for Prevention, Diagnosis, and Therapy.Frontiers in cardiovascular medicine · 2020Review
- Laser-based 3D bioprinting for spatial and size control of tumor spheroids and embryoid bodies.Acta biomaterialia · 2019Article
- Fas ligand and nitric oxide combination to control smooth muscle growth while sparing endothelium.Biomaterials · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveInvasive coronary interventions can fail due to intimal hyperplasia and restenosis. Endothelial cell (EC) seeding to the vessel lumen, accelerating re-endothelialization, or local release of mTOR pathway inhibitors have helped reduce intimal hyperplasia after vessel injury. While animal models are powerful tools, they are complex and expensive, and not always reflective of human physiology. Therefore, we developed an in vitro 3D vascular model validating previous in vivo animal models and utilizing isolated human arteries to study vascular remodeling after injury. APPROACH: We utilized a bioreactor that enables the control of intramural pressure and shear stress in vessel conduits to investigate the vascular response in both rat and human arteries to intraluminal injury.
resultsCulturing rat aorta segments in vitro, we show that vigorous removal of luminal ECs results in vessel injury, causing medial proliferation by Day-4 and neointima formation, with the observation of SCA1
conclusionOur bioreactor system provides a novel platform for correlating ex vivo findings with vascular outcomes in vivo. The present in vitro human arterial injury model can be helpful in the study of EC-SMC interactions and vascular remodeling, by allowing for the separation of mechanical, cellular, and soluble factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.