Evidence map›Paper›PMID 30094824›Full record

ArticleJournal of the American Geriatrics Society2018

Burden of Depressive Symptoms Over 2 Decades and Risk of Nursing Home Placement in Older Women.

Amy L Byers, Li-Yung Lui, Eric Vittinghoff, Kenneth E Covinsky, Kristine E Ensrud, Brent Taylor, Kristine Yaffe

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Contribution of Involuntary Job Loss to the Burden of Depressive Symptoms Over Two Decades in a National Study of Aging Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. Defining and Measuring Nursing Home Placement.Journal of the American Geriatrics Society · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Amy L ByersDepartment of Psychiatry, University of California, San Francisco, San Francisco, California.
Li-Yung LuiResearch Institute, California Pacific Medical Center, San Francisco, California.
Eric VittinghoffDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
Kenneth E CovinskySan Francisco Veterans Affairs Health Care System, San Francisco, California.
Kristine E EnsrudDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0002-9069-3036
Brent TaylorDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota.
Kristine YaffeDepartment of Psychiatry, University of California, San Francisco, San Francisco, California.

Funding

Study of Osteoporotic FracturesR01AG005407 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CUMMINGS, STEVEN RON, YAFFE, KRISTINE · 1986 to 2016
$23.2M
Changes in Sleep and Cognition in Older WomenR01AG026720 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI STONE, KATIE L, YAFFE, KRISTINE · 2006 to 2016
$7.5M
Study of Osteoporotic FracturesR01AG005394 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ENSRUD, KRISTINE · 1986 to 2015
$6.1M
HEALTH DECLINE IN AGED CAREGIVERS: EPIDEMIOLOGIC STUDYR01AG018037 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FREDMAN, LISA · 1999 to 2014
$5.9M
STUDY OF OSTEOPOROTIC FRACTURES: VERTEBRAL FRACTURESR01AR035583 · NIAMS · KAISER FOUNDATION RESEARCH INSTITUTE · PI HILLIER, TERESA A · 1986 to 2005
$3.2M
Pathways from Stress to Metabolic Syndrome and Health Decline in Aged CaregiversR01AG028144 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FREDMAN, LISA · 2007 to 2011
$3.1M
Study of Osteoporotic Fractures (SOF)R01AG027574 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI HILLIER, TERESA A · 2006 to 2015
$2.6M
Study of Osteoporotic Fractures (SOF)-Pittsburgh ClinicR01AG027576 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE ANN · 2006 to 2015
$2.4M
Study of Osteoporotic FracturesR01AR035582 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE · 1986 to 2005
$2.4M
Study of Osteoporotic FracturesR01AR035584 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI HOCHBERG, MARC C. · 1986 to 2005
$2.1M
Predictors & Outcomes of Cognitive Trajectories in the Oldest OldK24AG031155 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YAFFE, KRISTINE · 2007 to 2020
$1.5M
Long Term Depressive Symptom Course & Adverse Health Outcomes among Older WomenR01MH086498 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI YAFFE, KRISTINE · 2010 to 2012
$1.0M
CSRD VA I01 CX001119National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging AG026720National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging AG05394National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging AG05407National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging AR35582National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging AR35583National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging AR35584National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging R01 AG005394-2A1National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging R01 AG027574-22A1National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging R01 AG027576-22National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging R01 AG028144-1A1National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging R01AG18037National Institute on Minority Health and Health Disparities and Clinical Science Research & Development MD007019NIAMS NIH HHS R01 AR035582NIAMS NIH HHS R01 AR035583NIAMS NIH HHS R01 AR035584NIA NIH HHS AG031155NIA NIH HHS K24 AG031155NIA NIH HHS R01 AG005394NIA NIH HHS R01 AG005407NIA NIH HHS R01 AG026720NIA NIH HHS R01 AG027574NIA NIH HHS R01 AG027576NIA NIH HHS R01 AG028144NIMHD NIH HHS R01 MD007019NIMH NIH HHS R01 MH086498U.S. Department of Veterans Affairs Office of Research and Development CX001119
6 · The paper itself

Abstract

objectivesTo determine the association between cumulative burden of depressive symptoms and risk of nursing home (NH) placement over 2 decades.

designProspective cohort study with data linked to Medicare claims files.

settingClinic sites in Baltimore, Maryland; Minneapolis, Minnesota; and the Monongahela Valley near Pittsburgh, Pennsylvania.

participantsInitially community-dwelling women aged 65 and older (N=3,646). MEASUREMENTS: Depressive symptom burden was determined using the Geriatric Depression Scale measured over 18 years to calculate accumulation of burden. NH placement was determined using Medicare claims data.

resultsIn Fine-Gray proportional hazards analyses including demographic characteristics, medical comorbidities, functional impairment, and recent depression exposure and accounting for competing risk of death, women with low depressive symptom burden were twice as likely to experience NH placement as those with minimal burden (hazard ratio (HR) = 1.92, 95% confidence interval (CI) = 1.16-3.20), women with moderate burden were more than twice as likely (HR = 2.62, 95% CI = 1.59-4.31), and women with high burden (HR = 3.08, 95% CI = 1.87-5.08) were three times as likely. The addition of antidepressant use to this model attenuated the risk only slightly.

conclusionIn older women, cumulative burden of depressive symptoms over nearly 2 decades is associated with greater risk of transitioning from community-living to a NH irrespective of recent depression exposure, medical comorbidities, functional impairment, and the competing risk of death. This work supports the need for improving recognition, monitoring, and treatment of depressive symptoms early, which may reduce or delay NH placement.

Indexed as

Cost of IllnessAgedAged, 80 and overBaltimoreDepressionFemaleHomes for the AgedHumansMedicareMinnesotaNursing HomesPennsylvaniaProportional Hazards ModelsProspective StudiesRisk FactorsUnited Statesagingcare transitionsdepressionepidemiologyinstitutionalization

Identifiers

PMID30094824
PMCPMC6181760

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.