Evidence map›Paper›PMID 30094773›Full record

ArticleJournal of medical toxicology : official journal of the American College of Medical Toxicology2018

Monitoring Dose Response of Cyanide Antidote Dimethyl Trisulfide in Rabbits Using Diffuse Optical Spectroscopy.

Jangwoen Lee, Gary Rockwood, Brian Logue, Erica Manandhar, Ilona Petrikovics, Changhoon Han, Vik Bebarta, Sari B Mahon, Tanya Burney, Matthew Brenner

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Jangwoen LeeBeckman Laser Institute, University of California, 1002 Health Sciences Rd. East, Irvine, CA, 92612, USA. jangwl@uci.edu.ORCID 0000-0003-3822-2648
Gary RockwoodAnalytical Toxicology Division, US Army Medical Research Institute of Chemical Defense, 2900 Rickets Point Road, Aberdeen Proving Ground, Aberdeen, MD, 21010, USA.
Brian LogueDepartment of Chemistry and Biochemistry, South Dakota University, Brookings, SD, 57007, USA.
Erica ManandharDepartment of Chemistry and Biochemistry, South Dakota University, Brookings, SD, 57007, USA.
Ilona PetrikovicsDepartment of Chemistry, Sam Houston State University, Huntsville, TX, 77341, USA.
Changhoon HanDepartment of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang-si, Geonggi-do, 10444, South Korea.
Vik BebartaDepartment of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Sari B MahonBeckman Laser Institute, University of California, 1002 Health Sciences Rd. East, Irvine, CA, 92612, USA.
Tanya BurneyBeckman Laser Institute, University of California, 1002 Health Sciences Rd. East, Irvine, CA, 92612, USA.
Matthew BrennerBeckman Laser Institute, University of California, 1002 Health Sciences Rd. East, Irvine, CA, 92612, USA.
Beckman Laser Institute and Medical Clinic · USSouth Dakota State University · USNational Health Insurance Service Ilsan Hospital · KRSam Houston State University · USUniversity of California, Irvine · USUniversity of Colorado Denver · US

Funding

Pre-Clinical and Clinical Studies of Cobinamide, A New Cyanide Detoxifying AgentU01NS058030 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOSS, GERRY R · 2006 to 2017
$7.3M
ScientificU54NS063718 · NINDS · UNIVERSITY OF MINNESOTA · PI PATTERSON, STEVEN E · 2008 to 2011
$3.4M
Air Force Office of Scientific Research FA9550-14-1-0193Air Force Office of Scientific Research FA9550-17-1-0193Medical Research and Materiel Command W81XWH-12-2-0098NIH HHS 1U54 NS079201NIH HHS U01 NS058030NIH HHS U54 NS063718NINDS NIH HHS U01 NS058030NINDS NIH HHS U54 NS063718
6 · The paper itself

Abstract

introductionCyanide (CN) poisoning is a serious chemical threat from accidental or intentional exposures. Current CN exposure treatments, including direct binding agents, methemoglobin donors, and sulfur donors, have several limitations. Dimethyl trisulfide (DMTS) is capable of reacting with CN to form the less toxic thiocyanate with high efficiency, even without the sulfurtransferase rhodanese. We investigated a soluble DMTS formulation with the potential to provide a continuous supply of substrate for CN detoxification which could be delivered via intramuscular (IM) injection in a mass casualty situation. We also used non-invasive technology, diffuse optical spectroscopy (DOS), to monitor physiologic changes associated with CN exposure and reversal.

methodsThirty-six New Zealand white rabbits were infused with a lethal dose of sodium cyanide solution (20 mg/60 ml normal saline). Animals were divided into three groups and treated with saline, low dose (20 mg), or high dose (150 mg) of DMTS intramuscularly. DOS continuously assessed changes in tissue hemoglobin concentrations and cytochrome c oxidase redox state status throughout the experiment.

resultsIM injection of DMTS increased the survival in lethal CN poisoning. DOS demonstrated that high-dose DMTS (150 mg) reversed the effects of CN exposure on cytochrome c oxidase, while low dose (20 mg) did not fully reverse effects, even in surviving animals.

conclusionsThis study demonstrated potential efficacy for the novel approach of supplying substrate for non-rhodanese mediated sulfur transferase pathways for CN detoxification via intramuscular injection in a moderate size animal model and showed that DOS was useful for optimizing the DMTS treatment.

Indexed as

AnimalsAntidotesCarbon DioxideDose-Response Relationship, DrugElectron Transport Complex IVHemoglobinsOxidation-ReductionOxygen ConsumptionRabbitsSodium CyanideSpectrum AnalysisSulfidesSurvival AnalysisAntidotesCarbon Dioxidedimethyl trisulfideElectron Transport Complex IVHemoglobinsSodium CyanideSulfidesChemical and biological weaponsCyanide toxicity reversalDiffuse optical spectroscopyDimethyl trisulfideLethal cyanide poisoningOptical hemodynamic monitoring

Identifiers

PMID30094773
PMCPMC6242791
OpenAlexW2887355437

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.