ArticleNeurology and therapy2018
Injection of Onabotulinum Toxin A into the Bilateral External Oblique Muscle Attenuated Camptocormia: A Prospective Open-Label Study in Six Patients with Parkinson's Disease.
Article in Neurology and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Botulinum Toxin Effects on Freezing of Gait in Parkinson's Disease: A Systematic Review.Toxins · 2024Pooled it
- Botulinum Toxin for Axial Postural Abnormalities in Parkinson's Disease: A Systematic Review.Toxins · 2024Pooled it
- Efficacy and safety ofBMC neurology · 2026Trial
- Clinical Algorithm-Guided Approach to Botulinum Toxin Type A Treatment for Axial Postural Abnormalities in Parkinson's Disease.Movement disorders clinical practice · 2026Article
- Botulinum Neurotoxin Treatment of Camptocormia- A Critical Review and Update.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Review
- Camptocormia in Parkinson's disease: state of the art and future directions.Journal of neurology · 2025Review
- Review
- Treatment of axial postural abnormalities in parkinsonism disorders: A systematic review of pharmacological, rehabilitative and surgical interventions.Clinical parkinsonism & related disorders · 2024Article
- Use of botulinum toxin in the management of dystonia in Parkinson's disease.Frontiers in neuroscience · 2024Review
- Impact of deep brain stimulation therapy on the vertebral sagittal balance in Parkinson's disease patients.Neurosurgical review · 2023Article
- Article
- Botulinum toxin application to the internal and external oblique muscles for abdominal spasms in spinal cord injury.Spinal cord series and cases · 2021Article
- Review
- Spectrum of Truncal Dystonia and Response to Treatment: A Retrospective Analysis.Annals of Indian Academy of NeurologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCamptocormia (severe bending of the spine) is a debilitating complication of Parkinson's disease (PD) without established treatment. Botulinum toxin (BT) may be beneficial, but data is scarce regarding the efficacy of administration of BT into the bilateral external oblique (EO) muscle for treatment of camptocormia in PD.
methodsSix patients with PD and camptocormia, with flexion of the thoracic spine, were enrolled in the study. BT (75 or 90 units, onabotulinum toxin A) were injected into each EO bilaterally under sonographic guidance. Camptocormia angle (CA) was defined as the angle between the acromion-greater trochanter line and a vertical line. CA and disabling symptoms were evaluated during the treatment course.
resultsTwo weeks after the injection of BT, the mean CA showed significant attenuation [median (interquartile range); 38° (23.5°) vs. 18° (21°), p = 0.028]. Subjective relief was present in cases 1-3 and 6, and absent in cases 4 and 5. Cases 1-3 received repeated injections to maintain the amelioration; in cases 1 and 2, this was for 1 year or longer, while falls of case 3 limited the amelioration.
conclusionBotulinum therapy into bilateral EO attenuated the angle of thoracic-level camptocormia in six patients with PD over the observation period of 2 weeks. The reproducibility of the results, long-term efficacy, and subjective relief of symptoms require further examination.
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