ArticleNeurocritical care2019
The Risk of Takotsubo Cardiomyopathy in Acute Neurological Disease.
Article in Neurocritical care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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32 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Acute neurological disease as a trigger or co-occurrence of transient global amnesia: a case series and systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Genetic Overlap Between Dilated Cardiomyopathy and Neurological Disorders: Insights from a Next-Generation Sequencing Study.Diagnostics (Basel, Switzerland) · 2026Article
- Neurogenic shock to the heart: a rare case of meningitis-triggered reverse takotsubo cardiomyopathy.Proceedings (Baylor University. Medical Center) · 2026Article
- Neurogenic Stunned Myocardium: A Narrative Review of Cardiopulmonary Failure Related to Subarachnoidal Haemorrhage.Cureus · 2025Review
- Transient heart stunning revealing an acute intracranial infection.European journal of pediatrics · 2025Article
- The Heart-Brain Axis: Key Concepts in Neurocardiology.Cardiology discovery · 2025Review
- Leveraging the Capabilities of AI: Novice Neurology-Trained Operators Performing Cardiac POCUS in Patients with Acute Brain Injury.Neurocritical care · 2024Article
- Takotsubo Cardiomyopathy Following Insular Stroke in the M2 Area of the Left Middle Cerebral Artery.Cureus · 2024Article
- Simultaneous occurrence of transient global amnesia and Takotsubo syndrome triggered by caring for a terminally ill relative.Clinical case reports · 2024Article
- Neurological Disorders in Takotsubo Syndrome: Clinical Phenotypes and Outcomes.Journal of the American Heart Association · 2024Article
- Takotsubo Cardiomyopathy and Autoimmune Disorders: A Systematic Scoping Review of Published Cases.International journal of clinical practice · 2024Article
- An Extensive Review on Imaging Diagnosis Methods in Takotsubo Syndrome.Reviews in cardiovascular medicine · 2023Review
- Diagnosis and Management of Takotsubo Syndrome in Acute Aneurysmal Subarachnoid Hemorrhage: A Comprehensive Review.Reviews in cardiovascular medicine · 2023Review
- The Incidence of Takotsubo Cardiomyopathy in Patients with Intracerebral Hemorrhage: A US Nationwide Study.Neurocritical care · 2023Article
- The Octopus Trap of Takotsubo and Stroke: Genetics, Biomarkers and Clinical Management.Journal of personalized medicine · 2022Review
- Incidence and Outcomes of Registry-Based Acute Myocardial Infarction After Aneurysmal Subarachnoid Hemorrhage.Neurocritical care · 2022Article
- "Broken Heart" and "Broken Brain": Which Connection?Cardiology research · 2022Article
- A 'shark'-masked electrocardiogram: case report of a Tako-Tsubo syndrome.European heart journal. Case reports · 2021Article
- Ischemic Stroke and Heart Failure: Facts and Numbers. An Update.Journal of clinical medicine · 2021Review
- The Brain-Heart Link: A Case Report of a Critically Located Multiple Sclerosis Lesion in the Brainstem Leading to Recurrent Takotsubo Syndrome.Frontiers in cardiovascular medicine · 2021Article
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7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCase series have reported reversible left ventricular dysfunction, also known as stress cardiomyopathy or Takotsubo cardiomyopathy (TCM), in the setting of acute neurological diseases such as subarachnoid hemorrhage. The relative associations between various neurological diseases and Takotsubo remain incompletely understood.
methodsWe performed a cross-sectional study of all adults in the National Inpatient Sample, a nationally representative sample of US hospitalizations, from 2006 to 2014. Our exposures of interest were primary diagnoses of acute neurological disease, defined by ICD-9-CM diagnosis codes. Our outcome was a diagnosis of TCM. Binary logistic regression models were used to examine the associations between our pre-specified neurological diagnoses and TCM after adjustment for demographics.
resultsAmong acute neurological diagnoses, the strongest associations were seen with subarachnoid hemorrhage (odds ratio [OR] 11.7; 95% confidence interval [CI] 10.2-13.4), status epilepticus (OR 4.9; 95% CI 3.7-6.3), and seizures (OR 1.3; 95% CI 1.1-1.5). In a sensitivity analysis including secondary diagnoses of acute neurological diagnoses, associations were also seen with transient global amnesia (OR 2.3; 95% CI 1.5-3.6), meningoencephalitis (OR 2.1; 95% CI 1.7-2.5), migraine (OR 1.7; 95% CI 1.5-1.8), intracerebral hemorrhage (OR 1.3; 95% CI 1.1-1.5), and ischemic stroke (OR 1.2; 95% CI 1.1-1.3). In addition, female sex was strongly associated with Takotsubo (OR 5.1; 95% CI 4.9-5.4).
conclusionTCM appears to be associated with varying degrees with several acute neurological diseases besides subarachnoid hemorrhage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.