Evidence map›Paper›PMID 30094662›Full record

ArticleWiener klinische Wochenschrift2018

Extravascular lung water index and Halperin score to predict outcome in critically ill patients.

Bernhard Wernly, Sebastian Haumann, Maryna Masyuk, Johanna Muessig, Michael Lichtenauer, Laura Bäz, Marcus Franz, Alexander Pfeil, Alexander Lauten, Paul Christian Schulze and 5 more

Abstract read
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In one paragraph

Article in Wiener klinische Wochenschrift, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Bernhard WernlyClinic of Internal Medicine II, Department of Cardiology, Paracelsus Medical University of Salzburg, Salzburg, Austria.ORCID http://orcid.org/0000-0003-4024-0220
Sebastian HaumannInstitute of Diagnostic and Interventional Radiology, Jena University Hospital, Jena, Germany.
Maryna MasyukDivision of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Moorenstraße 5, 40225, Duesseldorf, Germany.
Johanna MuessigDivision of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Moorenstraße 5, 40225, Duesseldorf, Germany.
Michael LichtenauerClinic of Internal Medicine II, Department of Cardiology, Paracelsus Medical University of Salzburg, Salzburg, Austria.
Laura BäzClinic of Internal Medicine I, Department of Cardiology, Jena University Hospital, Jena, Germany.
Marcus FranzClinic of Internal Medicine I, Department of Cardiology, Jena University Hospital, Jena, Germany.
Alexander PfeilClinic of Internal Medicine III, Jena University Hospital, Jena, Germany.
Alexander LautenDepartment of Cardiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Paul Christian SchulzeClinic of Internal Medicine I, Department of Cardiology, Jena University Hospital, Jena, Germany.
Uta C HoppeClinic of Internal Medicine II, Department of Cardiology, Paracelsus Medical University of Salzburg, Salzburg, Austria.
Malte KelmDivision of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Moorenstraße 5, 40225, Duesseldorf, Germany.
Ralf WestenfeldDivision of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Moorenstraße 5, 40225, Duesseldorf, Germany.
Christian JungDivision of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Moorenstraße 5, 40225, Duesseldorf, Germany. christian.jung@med.uni-duesseldorf.de.
Diane RenzInstitute of Diagnostic and Interventional Radiology, Jena University Hospital, Jena, Germany.
Jena University Hospital · DEHeinrich Heine University Düsseldorf · DEUniversity of Salzburg · ATDeutsches Herzzentrum der Charité · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to describe real world extravascular lung water index (EVLWI) measurements obtained by pulse index continuous cardiac output (PiCCO) on the day of admission. These were then related to a radiologic score for lung edema, Halperin score and both the Halperin score and EVLWI were assessed for prediction of in-hospital mortality in critically ill patients. METHODS AND

resultsA total of 311 patients admitted to a tertiary medical university hospital between February 2004 and December 2010 were included in this retrospective analysis and of these 177 patients were intubated. In-hospital mortality was assessed by logistic regression. In the overall cohort, EVLWI and the Halperin score correlated poorly (r = 0.17; p = 0.02). In intubated patients, EVLWI and Halperin score did not correlate (r = 0.09; p = 0.39), whereas in patients who were not intubated there was a moderate association (r = 0.30; p = 0.007). In the overall cohort, (a) EVLWI (hazard ratio [HR] 1.10, 95% confidence interval [CI] 1.02-1.19; p = 0.01; area under the curve [AUC] 0.63, 95% CI 0.54-0.71) but not (b) Halperin score (HR 1.00, 95% CI 0.996-1.004; p = 0.94; AUC 0.52, 95% CI 0.45-0.58) was associated with in-hospital mortality There was a robust association of EVLWI (HR 1.12, 95% CI 1.01-1.25; p = 0.03) but not Halperin score (HR 1.003, 95% CI 0.997-1.009; p = 0.30) with mortality in non-intubated patients. In intubated patients, neither EVLWI (HR 0.997 95% CI 0.990-1.003; p = 0.33) nor Halperin score (HR 1.08; 95% CI 0.88-1.32; p = 0.47) was associated with mortality.

conclusionThe EVLWI correlated moderately with a radiologic score for lung edema, the Halperin score, in non-intubated but not in intubated patients. The EVLWI at admission was associated with in-hospital mortality in our patient collective of critically ill patients and might constitute not only a tool for risk stratification but most importantly a valuable treatment goal.

Indexed as

Critical IllnessExtravascular Lung WaterPulmonary EdemaCardiac OutputFemaleHumansLungMaleMiddle AgedPrognosisRetrospective StudiesCritical careCritically illIntensive care unitInvasive hemodynamic measurementPulse contour cardiac output

Identifiers

PMID30094662
OpenAlexW2885138610

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.