ArticleMikrochimica acta2018
Dual-aptamer based electrochemical sandwich biosensor for MCF-7 human breast cancer cells using silver nanoparticle labels and a poly(glutamic acid)/MWNT nanocomposite.
Article in Mikrochimica acta, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 107 citations in OpenAlex.
- Application of green synthesized WOScientific reports · 2021Trial
- Label-free electrochemical aptasensing of cardiac cell secretomes in cell culture media for the evaluation of drug-induced myocardial injury.Journal of pharmaceutical analysis · 2025Article
- Designing the Future of Biosensing: Advances in Aptamer Discovery, Computational Modeling, and Diagnostic Applications.Biosensors · 2025Review
- Recent advances of silver nanoparticle-based polymer nanocomposites for biomedical applications.RSC advances · 2025Review
- Multiplex electrochemical sensing platforms for the detection of breast cancer biomarkers.Frontiers in medical technology · 2024Review
- Conductive Polymers and Their Nanocomposites: Application Features in Biosensors and Biofuel Cells.Polymers · 2023Review
- Scope of Onsite, Portable Prevention Diagnostic Strategies forBiosensors · 2023Review
- Label-Free Electrochemical Aptasensor for Sensitive Detection of Malachite Green Based on AuNPs/MWCNTs@TiOInternational journal of molecular sciences · 2023Article
- Signaling strategies of silver nanoparticles in optical and electrochemical biosensors: considering their potential for the point-of-care.Mikrochimica acta · 2023Review
- Self-assembled supramolecular immunomagnetic nanoparticles through π-π stacking strategy for the enrichment of circulating tumor cells.Regenerative biomaterials · 2023Article
- Functionalized Silver and Gold Nanomaterials with Diagnostic and Therapeutic Applications.Pharmaceutics · 2022Review
- Molecularly imprinted polymers outperform lectin counterparts and enable more precise cancer diagnosis.Chemical science · 2022Article
- Multivalent Aptamer Approach: Designs, Strategies, and Applications.Micromachines · 2022Review
- Three-dimensional porous calcium alginate fluorescence bead-based immunoassay for highly sensitive early diagnosis of breast cancer.Analytical and bioanalytical chemistry · 2022Article
- A Comparison between Silver Nanosquare Arrays and Silver Thin-Films as a Blood Cancer Prognosis Monitoring Electrode Design Using Optical and Electrochemical Characterization.Nanomaterials (Basel, Switzerland) · 2021Article
- Recent Development of Nanomaterials-Based Cytosensors for the Detection of Circulating Tumor Cells.Biosensors · 2021Review
- Electrochemical Sensors for Detection of Markers on Tumor Cells.International journal of molecular sciences · 2021Review
- Polymers in Sensor and Biosensor Design.Polymers · 2021Article
- Recent Advances in Electrochemical Sensors for the Detection of Biomolecules and Whole Cells.Biomedicines · 2020Review
- Recent advances and challenges in electrochemical biosensors for emerging and re-emerging infectious diseases.Journal of electroanalytical chemistry (Lausanne, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper reports on a sensitive and selective method for the detection of Michigan Cancer Foundation-7 (MCF-7) human breast cancer cells and MUC1 biomarker by using an aptamer-based sandwich assay. A biocompatible nanocomposite consisting of multiwall carbon nanotubes (MWCNT) and poly(glutamic acid) is placed on a glassy carbon electrode (GCE). The sandwich assay relies on the use of a mucin 1 (MUC1)-binding aptamer that is first immobilized on the surface of modified GCE. Another aptamer (labeled with silver nanoparticles) is applied for secondary recognition of MCF-7 cells in order to increase selectivity and produce an amplified signal. Differential pulse anodic stripping voltammetry was used to follow the electrochemical signal of the AgNPs. Under the optimal condition, the sensor responds to MCF-7 cells in the concentration range from 1.0 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.