Evidence map›Paper›PMID 30094593›Full record

ReviewCurrent psychiatry reports2018

The Intersection of Sex Differences, Tobacco Use, and Inflammation: Implications for Psychiatric Disorders.

Rebecca L Ashare, Reagan R Wetherill

Abstract readReview
In one paragraph

Review in Current psychiatry reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Natural killer cells in multiple sclerosis: foe or friends?Frontiers in cellular neuroscience · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Sex and gender in respiratory physiology.European respiratory review : an official journal of the European Respiratory Society · 2021
    Article
  13. Review
  14. Review
  15. Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021
    Article
  16. Bidirectional Associations among Nicotine and Tobacco Smoke, NeuroHIV, and Antiretroviral Therapy.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rebecca L AshareDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Suite 4100, Philadelphia, PA, 19104, USA. rlashare@pennmedicine.upenn.edu.
Reagan R WetherillDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Suite 4100, Philadelphia, PA, 19104, USA.
University of Pennsylvania · US

Funding

Targeting the Cholinergic Pathway in HIV-associated Inflammation and Cognitive DysfunctionR01DA044906 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI ASHARE, REBECCA, COLLMAN, RONALD G · 2017 to 2021
$3.8M
Understanding the Role of Cognitive Dysfunction in the Treatment of Nicotine Dependence among HIV-Infected SmokersR01DA042682 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI ASHARE, REBECCA · 2016 to 2020
$3.3M
Influence of the natural hormonal milieu on perfusion fMRI smoking cue responsesR01DA040670 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI WETHERILL, REAGAN R · 2016 to 2020
$2.4M
Effectiveness of Bavisant:Characterizing Individual DifferencesK23AA023894 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI WETHERILL, REAGAN R · 2015 to 2019
$856k
NIAAA NIH HHS K23 AA023894NIDA NIH HHS R01 DA040670NIDA NIH HHS R01 DA042682NIDA NIH HHS R01 DA044906
6 · The paper itself

Abstract

purpose of reviewTobacco use, sex differences, and psychiatric disorders are associated with altered immune function. There are also sex differences in tobacco use and psychiatric disorders. This review summarizes findings from the small, but growing literature examining sex differences in the effects of tobacco use on inflammation and the implications for psychiatric disorders. RECENT

findingsWe identified four studies that tested the interaction between sex and tobacco/nicotine on inflammation. Although males and females generally exhibited differential tobacco-induced immune responses, the pattern varied depending on the sample (rodents vs. humans) and the method to evaluate inflammation. Evidence suggests that sex modulates the effects of tobacco smoke on inflammation. Many inflammation markers associated with sex differences and tobacco use are related to psychiatric disorders. We propose a model in which sex, tobacco use, and inflammation interact to increase risk for psychiatric disorders. Future studies are needed to examine the mechanisms that explain this relationship.

Indexed as

Sex CharacteristicsTobacco UseAnimalsFemaleHumansInflammationMaleMental DisordersNicotineSmokingNicotineImmune functionInflammationNicotinePsychiatric disordersSex differencesTobacco

Identifiers

PMID30094593
PMCPMC7018440
OpenAlexW2887377710

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.