Evidence map›Paper›PMID 30094505›Full record

ArticleJournal of materials science. Materials in medicine2018

A combined approach for the development of novel sutures with antibacterial and regenerative properties: the role of silver and silk sericin functionalization.

Anna Lucia Gallo, Mauro Pollini, Federica Paladini

Abstract read
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In one paragraph

Article in Journal of materials science. Materials in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anna Lucia GalloDepartment of Engineering for Innovation, University of Salento, Via Monteroni, Lecce, 73100, Italy.
Mauro PolliniDepartment of Engineering for Innovation, University of Salento, Via Monteroni, Lecce, 73100, Italy. mauro.pollini@unisalento.it.
Federica PaladiniDepartment of Engineering for Innovation, University of Salento, Via Monteroni, Lecce, 73100, Italy.
University of Salento · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic wounds and related infections cause physical and psychological distress in patients, increased mortality, disability and high health care costs. The healing process can be delayed by several factors and in particular by the risk of infections, which can be further complicated by the increasing number of antibiotic-resistant microorganisms. New approaches in wounds management have been encouraged, aiming at preventing infections and improving wound healing. In this scenario, silver has emerged as an ideal antimicrobial agent due to its recognized efficacy against bacteria, viruses and fungi. Moreover, silk and in particular silk sericin from Bombyx mori has demonstrated excellent biological properties and can be considered a good candidate for skin tissue engineering. In this study absorbable PLGA sutures were functionalized with silk sericin and, then, they were treated with silver through an in situ photochemical deposition technology in order to develop an antibacterial and regenerative biomedical device. Morphological analysis was performed by Scanning Electron Microscopy and Energy Dispersive X-Ray Spectroscopy (SEM-EDX) in order to evaluate the presence and distribution of silver deposited on the sutures. The stability and durability of the sericin/silver coatings were tested and the results were related to both antibacterial properties and sample degradation. The biological analyses also aimed at studying the biocompatibility and wound healing properties of the device, evaluating the synergistic effect between sericin and silver.

Indexed as

SuturesAnimalsAnti-Bacterial AgentsBacteriaBiocompatible MaterialsFibroblastsGuided Tissue RegenerationLactic AcidMicroscopy, Electron, ScanningPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerSericinsSilverSpectrometry, X-Ray EmissionAnti-Bacterial AgentsBiocompatible MaterialsLactic AcidPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerSericinsSilver

Identifiers

PMID30094505
OpenAlexW2885737463

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.