SynthesisNeurosurgical review2020
Depression and glioblastoma, complicated concomitant diseases: a systemic review of published literature.
Synthesis in Neurosurgical review, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07409584 (Mental Health and Suicidality in Glioblastoma Patients in Germany - a Multicenter Observational Study), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mental Health and Suicidality in Glioblastoma Patients in Germany - a Multicenter Observational Study (SHINE-GLIO Study)
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Antidepressant drugs and risk of developing glioma: a national registry-based case-control study and a meta-analysis.American journal of epidemiology · 2024Pooled it
- Trial
- Discovery of novel Kir4.1 inhibitors based on serdemetan with potential therapy for glioblastoma-depression comorbidity.Pharmaceutical science advances · 2026Article
- Signs of antidepressant-like effects of temozolomide as measured in the forced-swim test in adult rats.Pharmacological reports : PR · 2026Article
- Mental health and suicidality in glioblastoma patients in germany - a multicenter cross-sectional observational study protocol (SHINE-GLIO Study).Neurological research and practice · 2026Article
- Gender role in radiotherapy: psychosocial differences between males and females during cancer care : Single-centre report on adult and paediatric oncological patients.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- Effects of Glioblastoma Resection on Cognitive Function and Affective Symptoms at Three-Month Follow-Up.Brain and behavior · 2026Observational
- Antidepressant-like effects of cannabidiol when combined with temozolomide in adult rats.Frontiers in pharmacology · 2026Article
- Survival outcomes associated with antidepressant use in glioblastoma: a cohort study.Journal of neuro-oncology · 2025Article
- Three Major Deficiency Diseases Harming Mankind (Protein, Retinoid, Iron) Operate Under Tryptophan Dependency.Nutrients · 2025Review
- Empower GBM: A pilot study of a patient-caregiver supportive intervention for patients with glioblastoma.Palliative & supportive care · 2025Article
- Article
- Sleep disturbances in brain tumors: a narrative review.Frontiers in oncology · 2025Review
- Development of preoperative and postoperative models to predict recurrence in postoperative glioma patients: a longitudinal cohort study.BMC cancer · 2024Article
- Developing behavioural activation for people with acquired brain injury: a qualitative interpretive description study of barriers and facilitators to activity engagement.BMC psychology · 2023Article
- Preoperative symptoms of depression, anxiety, and cognitive impairment in glioma patients: A cerebral perfusion CT study.Brain and behavior · 2023Article
- Depression in brain tumor patients-early detection and screening.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Brain Tumor at Diagnosis: From Cognition and Behavior to Quality of Life.Diagnostics (Basel, Switzerland) · 2023Review
- Neurocognitive impairment, neurobehavioral symptoms, fatigue, sleep disturbance, and depressive symptoms in patients with newly diagnosed glioblastoma.Neuro-oncology practice · 2023Article
- Predictive models and survival analysis of postoperative mental health disturbances in adult glioma patients.Frontiers in oncology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glioblastoma multiforme (GBM) is the most common primary brain cancer. Depression is a common co-morbidity of this condition. Despite this common interaction, relatively little research has been performed on the development of GBM-associated depression. We performed a literary search of the PubMed database for articles published relating to GBM and depression. A total of 85 articles were identified with 46 meeting inclusion criteria. Depression significantly impacts care, decreasing medication compliance, and patient survival. Diagnostically, because depression and GBM share intricate neuro-connectivity in a way that effect functionality, these diseases can be mistaken for alternative psychological or pathological disorders, complicating care. Therapeutically, anti-depressants have anti-tumor properties; yet, some have been shown to interfere with GBM treatment. One reason for this is that the pathophysiological development of depression and GBM share several pathways including altered regulation of the 5-HT receptor, norepinephrine, and 3':5'-cyclic monophosphate. Over time, depression can persist after GBM treatment, affecting patient quality of life. Together, depression and GBM are complicated concomitant diseases. Clinicians must be aware of their co-existence. Because of overlapping molecular pathways involved in both diseases, careful medication selection is imperative to avoid potential adverse interactions. Since GBMs are the most common primary brain cancer, physicians dealing with this disease should be prepared for the development of depression as a potential sequela of this condition, given the related pathophysiology and the known poor outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.