Evidence map›Paper›PMID 30094404›Full record

ArticleHepatology communications2018

Prognostic Significance of Controlled Attenuation Parameter in Patients With Compensated Advanced Chronic Liver Disease.

Cristina Margini, Giuseppe Murgia, Guido Stirnimann, Andrea De Gottardi, Nasser Semmo, Stefania Casu, Jaime Bosch, Jean-François Dufour, Annalisa Berzigotti

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Prevalence of and risk factors for anaemia in patients with advanced chronic liver disease.Liver international : official journal of the International Association for the Study of the Liver · 2020
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Cristina MarginiSwiss Liver Center, Hepatology University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern Bern Switzerland.
Giuseppe MurgiaSwiss Liver Center, Hepatology University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern Bern Switzerland.
Guido StirnimannSwiss Liver Center, Hepatology University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern Bern Switzerland.
Andrea De GottardiSwiss Liver Center, Hepatology University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern Bern Switzerland.
Nasser SemmoSwiss Liver Center, Hepatology University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern Bern Switzerland.
Stefania CasuSwiss Liver Center, Hepatology University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern Bern Switzerland.
Jaime BoschSwiss Liver Center, Hepatology University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern Bern Switzerland.
Jean-François DufourSwiss Liver Center, Hepatology University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern Bern Switzerland.
Annalisa BerzigottiSwiss Liver Center, Hepatology University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern Bern Switzerland.
University Hospital of Bern · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity and steatosis have been associated with liver disease progression in patients with compensated advanced chronic liver disease (cACLD) (liver stiffness measurement [LSM] ≥ 10 kPa). The controlled attenuation parameter (CAP) estimates steatosis during LSM by transient elastography. We aimed to evaluate whether CAP is associated with the development of clinically relevant events in cACLD. Consecutive patients with cACLD and CAP measurements observed between September 2013 and September 2015 were retrospectively studied. Classical decompensation and severe bacterial infections on follow-up were recorded. A predefined CAP cut-off for steatosis was used (220 dB/m; 90% sensitivity). The association among LSM, CAP, and events was assessed by univariate and multivariate Cox regression. Among the 193 patients (viral etiology = 58%; median Child score = 5; LSM = 15.1 kPa; CAP = 255 ± 62 dB/m) who were followed up in median for 18 months, 18 developed clinically relevant events (11 liver decompensation, 7 severe bacterial infections). Patients developing events had higher LSM (median: 30.8 versus 14.3 kPa,

Identifiers

PMID30094404
PMCPMC6078211
OpenAlexW2883099180

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.