ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2018
Relationship between frailty and Alzheimer's disease biomarkers: A scoping review.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Frailty and Health Outcomes in People 65 Years or Older Living With Dementia: A Systematic Review of the Literature.Journal of the American Geriatrics Society · 2026Pooled it
- Grip strength modifies the association between blood-based alzheimer's biomarkers and cognitive function.GeroScience · 2026Article
- Multifactorial analysis of risk factors for frailty and cognitive frailty among hospitalized patients.BMC geriatrics · 2026Article
- Exploring Frailty Status and Blood Biomarkers: A Multidimensional Approach to Alzheimer's Diagnosis.Geriatrics (Basel, Switzerland) · 2025Article
- Cortico-Cortical Paired Associative Stimulation (ccPAS) in Ageing and Alzheimer's Disease: A Quali-Quantitative Approach to Potential Therapeutic Mechanisms and Applications.Brain sciences · 2025Article
- Tau protein mediates the association between frailty and postoperative delirium: a machine learning model incorporating cerebrospinal fluid biomarkers.Frontiers in neurology · 2025Article
- Non-Cognitive Symptoms in Alzheimer's Disease and Their Likely Impact on Patient Outcomes. A Scoping Review.Current treatment options in neurology · 2025Article
- The impact of frailty on cognitive outcomes in elderly patients with post-stroke subjective cognitive complaints.Frontiers in neurology · 2025Article
- Cerebrospinal fluid proteomic profile of frailty: Results from the PROLIPHYC cohort.Aging cell · 2024Article
- Midlife cumulative deficit frailty predicts Alzheimer's disease-related plasma biomarkers in older adults.Age and ageing · 2024Article
- Behavioral, metabolic, and lipidomic characterization of the 5xFADxTg30 mouse model of Alzheimer's disease.iScience · 2024Article
- To Be Frail or Not to Be Frail: This Is the Question-A Critical Narrative Review of Frailty.Journal of clinical medicine · 2024Review
- Dissecting the shared genetic architecture between Alzheimer's disease and frailty: a cross-trait meta-analyses of genome-wide association studies.Frontiers in genetics · 2024Article
- Frailty Is Associated With Cognitive Decline Independent of Cerebral Small Vessel Disease and Brain Atrophy.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Salivary Inflammatory Molecules as Biomarkers of Sleep Alterations: A Scoping Review.Diagnostics (Basel, Switzerland) · 2021Article
- Translational Modeling of Psychomotor Function in Normal and AD-Pathological Aging With Special Concerns on the Effects of Social Isolation.Frontiers in aging · 2021Article
- Pharmacological intervention in a transgenic mouse model improves Alzheimer's-associated pathological phenotype: Involvement of proteasome activation.Free radical biology & medicine · 2021Article
- Investigating Neuroimaging Correlates of Early Frailty in Patients With Behavioral Variant Frontotemporal Dementia: A MRI and FDG-PET Study.Frontiers in aging neuroscience · 2021Article
- Neuropathologic burden and the degree of frailty in relation to global cognition and dementia.Neurology · 2020Article
- An opinion paper on the maintenance of robustness: Towards a multimodal and intergenerational approach using digital twins.Aging medicine (Milton (N.S.W)) · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFrailty and dementia appear to be closely linked, although mechanisms remain unclear. The objective was to conduct a scoping review of the association between frailty and Alzheimer's disease (AD) biomarkers in humans.
methodsThree databases, PubMed, PsycINFO, and Embase, were searched for articles using the following search terms: "frail elderly", "Alzheimer's disease", "dementia biomarkers" and their synonyms. Inclusion was limited to original research in humans published before 2017, which included a frailty measure and AD biomarker (fluid markers, neuroimaging, and neuropathology).
resultsFive hundred twenty-two articles were identified and screened; 10 were included. Most were cross-sectional (n = 6), measured the frailty phenotype (n = 6), and included people with dementia (n = 7). Biomarkers examined were postmortem AD pathology (n = 3), brain atrophy (n = 5), and in vivo fluid markers (n = 2). Eight studies reported that increased frailty was associated with at least one biomarker abnormality. DISCUSSION: Evidence is limited and suffers from design limitations but suggests that frailty and AD biomarkers are closely linked. Longitudinal research examining multiple biomarkers and frailty is warranted.
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