Evidence map›Paper›PMID 30094297›Full record

ArticleBone reports2018

Characteristics of bone strength and metabolism in type 2 diabetic model Tsumura, Suzuki, Obese Diabetes mice.

Hiroaki Tanaka, Takenori Yamashita, Misao Yoneda, Satoshi Takagi, Toshihiro Miura

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Therapeutic Potential ofFrontiers in pharmacology · 2020
    Review
  6. The Effect of Type 2 Diabetes on Bone Biomechanics.Current osteoporosis reports · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hiroaki TanakaGraduate School of Health Science Suzuka University of Medical Science, 1001-1 Kishioka, Suzuka, Mie 510-0293, Japan.
Takenori YamashitaDepartment of Radiological Technology, Faculty of Health Science, Suzuka University of Medical Science, 1001-1 Kishioka, Suzuka, Mie 510-0293, Japan.
Misao YonedaDepartment of Clinical Nutrition, Faculty of Health Science, Suzuka University of Medical Science, 1001-1 Kishioka, Suzuka, Mie 510-0293, Japan.
Satoshi TakagiDepartment of Physical Therapy, Faculty of Health and Medical Sciences, Tokoha University, 1230 Miyakoda, Kitaku, Hamamatsu, Shizuoka, 431-2102, Japan.
Toshihiro MiuraGraduate School of Health Science Suzuka University of Medical Science, 1001-1 Kishioka, Suzuka, Mie 510-0293, Japan.
Suzuka University of Medical Science · JPTokoha Gakuen University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveType 2 diabetes mellitus (T2DM) is a metabolic disease characterized by hyperglycemia, hyperinsulinemia, and complications such as obesity and osteoporosis. The Tsumura, Suzuki, Obese Diabetes (TSOD) mouse is an animal model of spontaneous obese T2DM. However, bone metabolism in TSOD mice is yet to be investigated. The objective of the present study was to investigate the effects of T2DM on bone mass, metabolism, microstructure, and strength in TSOD mice.

methodsWe determined the following parameters in TSOD mice and Tsumura, Suzuki, Non-obesity (TSNO) mice (as controls): serum glucose levels; serum insulin levels; bone mass; bone microstructure; bone metabolic markers; and bone strength. We also performed the oral glucose tolerance test and examined histological sections of the femur. We compared these data between both groups at pre-diabetic (10 weeks) and established (20 weeks) diabetic conditions.

resultsBone strength, such as extrinsic mechanical properties, increased with age in the TSOD mice and intrinsic material properties decreased at both 10 weeks and 20 weeks. Bone resorption marker levels in TSOD mice were significantly higher than those in the control mice at both ages, but there was no significant difference in bone formation markers between the groups. Bone mass in TSOD mice was lower than that in controls at both ages. The trabecular bone volume at the femoral greater trochanter increased with age in the TSOD mice. The femoral mid-diaphysis in TSOD mice was more slender and thicker than that in TSNO mice at both ages.

conclusionsBone mass of the femur was lower in TSOD mice than in TSNO mice because hyperinsulinemia during pre-diabetic and established diabetic conditions enhanced bone resorption due to high bone turnover. In addition, our data suggest that the bone mass of the femur was significantly reduced as a result of chronic hyperglycemia during established diabetic conditions in TSOD mice. We suggest that bone strength in the femur deteriorated due to the reduction of bone mass and because the femoral mid-diaphysis was more slender in TSOD mice.

Indexed as

BMC, bone mineral contentBMD, bone mineral densityBone massBone metabolismBone microstructureBone strengthCSMI, cross-sectional moment inertiamicro-CT, micro-computed tomographyOCN, osteocalcinOGTT, oral glucose tolerance testPBS, phosphate-buffered salineT1DM, type 1 diabetes mellitusT2DM, type 2 diabetes mellitusTRAcP5b, tartrate-resistant acid phosphatase 5bTSNO, Tsumura, Suzuki, non-obesityTSOD, Tsumura, Suzuki, Obese DiabetesTsumura, Suzuki, Obese Diabetes miceType 2 diabetes mellitus

Identifiers

PMID30094297
PMCPMC6073051
OpenAlexW2884045202

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.