Evidence map›Paper›PMID 30094093›Full record

ArticleAmerican journal of cancer research2018

A deficiency in cathelicidin reduces lung tumor growth in NNK/NTHi-induced A/J mice.

Yiwen Yao, Junlu Wu, Hao Zhou, Jenni Firrman, Weidong Xiao, Zujun Sun, Dong Li

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yiwen YaoDepartment of Clinical Laboratory, Shanghai Tongji Hospital, Tongji University School of Medicine Shanghai 200065, China.
Junlu WuDepartment of Clinical Laboratory, Shanghai Tongji Hospital, Tongji University School of Medicine Shanghai 200065, China.
Hao ZhouDepartment of Pharmacy, Putuo People's Hospital Shanghai 200060, China.
Jenni FirrmanDairy and Functional Foods Research Unit, Eastern Regional Research Center, Agricultural Research Service, United States Department of Agriculture Wyndmoor, PA 19038, USA.
Weidong XiaoSol Sherry Thrombosis Research Center, Temple University 19140 Philadelphia, PA, USA.
Zujun SunDepartment of Clinical Laboratory, Shanghai Tongji Hospital, Tongji University School of Medicine Shanghai 200065, China.
Dong LiDepartment of Clinical Laboratory, Shanghai Tongji Hospital, Tongji University School of Medicine Shanghai 200065, China.
Temple University · US

Funding

Molecular Biology of Recombinant AAV GenomesR01HL080789 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI XIAO, WEIDONG · 2006 to 2014
$3.1M
Novel adeno-associated virus vector production system developmentR01HL114152 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI XIAO, WEIDONG · 2012 to 2016
$2.2M
NHLBI NIH HHS R01 HL080789NHLBI NIH HHS R01 HL114152
6 · The paper itself

Abstract

Cathelicidin is an antimicrobial peptide that plays an essential role in cell proliferation, angiogenesis, and also has been indicated in tumor promotion. However, it is unclear how cathelicidin causes tumor growth, and the pathogenic mechanisms based on gain or loss of function have not been proposed. Here, a cathelicidin related antimicrobial peptide (CRAMP) knockout mouse was generated using an A/J background (A/J-CRAMP

Indexed as

A/J miceCathelicidinlung cancerNNK/NTHi

Identifiers

PMID30094093
PMCPMC6079153
OpenAlexW3021187601

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.