ReviewJournal of advanced research2018
Ureases: Historical aspects, catalytic, and non-catalytic properties - A review.
Review in Journal of advanced research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 253 citations in OpenAlex.
- Comparative phylogenomics of bacterial urease systems reveals architectural conservation, lineage-specific specialization, and candidate horizontal transfer.Molecular genetics and genomics : MGG · 2026Article
- Urease Inhibitors fromACS pharmacology & translational science · 2026Article
- Abiotic sources of fixed nitrogen sustained early ecosystems for several hundred million years after the origin of life.Science advances · 2026Article
- Food Biotechnology Potential of Grape-DerivedFoods (Basel, Switzerland) · 2026Article
- Design, synthesis and biological profiling of bis-thiazole linked Schiff bases as effective enzyme inhibitors for targeting urease and thymidine phosphorylase proteins.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- A One Health Perspective onMicroorganisms · 2026Review
- Unraveling the Pathogenetic Potential and Immune Crosstalk of Yersinia spp. in Inflammatory Bowel Disease.Journal of immunology research · 2026Review
- Review
- Exploring Wheat Leaf Urease for a Sustainable Approach: Purification, Kinetics, and Thermal Stability Characterization.The protein journal · 2025Article
- Aptamer-based colorimetric detection of ATP and PDGF-BB by silver nanoparticles-mediated signal amplification and urease activity inhibition.Mikrochimica acta · 2025Article
- Harnessing microbial-derived metabolites in the urinary tract to prevent infection induced catheter encrustation.Nature communications · 2025Article
- Comprehensive Evaluation of Biogas Slurry Fertility: A Study Based on the Effects of Biogas Slurry Irrigation on Soil Microorganisms and Enzyme Activities in Winter Wheat Fields.Microorganisms · 2025Article
- Piceatannol, a Natural Polyphenol From Grape, InhibitsFood science & nutrition · 2025Article
- Cross-talk between Pseudomonas aeruginosa and urinary tract infections.World journal of urology · 2025Review
- Anti-urease therapy: a targeted approach to mitigating antibiotic resistance in Helicobacter pylori while preserving the gut microflora.Gut pathogens · 2025Review
- Allicin enhances urea-N conversion to microbial-N by inhibiting urease activity and modulating the rumen microbiome in cattle.Microbiome · 2025Article
- Linking the Metabolic Activity of Plastic-Degrading Fungi to Their Taxonomy and Evolution.Journal of fungi (Basel, Switzerland) · 2025Review
- Discovery ofFuture medicinal chemistry · 2025Article
- Fur-regulated urease contributes to the environmental adaptation ofMicrobiology spectrum · 2025Article
- Nitrogen metabolism of the highly ureolytic bacterium Proteus penneri S99 isolated from the rumen.BMC microbiology · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urease (urea amidohydrolase, EC 3.5.1.5) is a nickel-containing enzyme produced by plants, fungi, and bacteria that catalyzes the hydrolysis of urea into ammonia and carbamate. Urease is of historical importance in Biochemistry as it was the first enzyme ever to be crystallized (1926). Finding nickel in urease's active site (1975) was the first indication of a biological role for this metal. In this review, historical and structural features, kinetics aspects, activation of the metallocenter and inhibitors of the urea hydrolyzing activity of ureases are discussed. The review also deals with the non-enzymatic biological properties, whose discovery 40 years ago started a new chapter in the study of ureases. Well recognized as virulence factors due to the production of ammonia and alkalinization in diseases by urease-positive microorganisms, ureases have pro-inflammatory, endocytosis-inducing and neurotoxic activities that do not require ureolysis. Particularly relevant in plants, ureases exert insecticidal and fungitoxic effects. Data on the jack bean urease and on jaburetox, a recombinant urease-derived peptide, have indicated that interactions with cell membrane lipids may be the basis of the non-enzymatic biological properties of ureases. Altogether, with this review we wanted to invite the readers to take a second look at ureases, very versatile proteins that happen also to catalyze the breakdown of urea into ammonia and carbamate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.