ArticleLupus science & medicine2018
Measuring lupus arthritis activity using contrasted high-field MRI. Associations with clinical measures of disease activity and novel patterns of disease.
Article in Lupus science & medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Concordance and discordance in SLE clinical trial outcome measures: analysis of three anifrolumab phase 2/3 trials.Annals of the rheumatic diseases · 2022Trial
- Musculoskeletal manifestations of systemic lupus erythematosus.Skeletal radiology · 2025Review
- Update on Current Imaging of Systemic Lupus Erythematous in Adults and Juveniles.Journal of clinical medicine · 2022Review
- A Narrative Literature Review Comparing the Key Features of Musculoskeletal Involvement in Rheumatoid Arthritis and Systemic Lupus Erythematosus.Rheumatology and therapy · 2022Review
- Evaluation of SLE arthritis using frequency domain optical imaging.Lupus science & medicine · 2021Article
- Imaging of Joint and Soft Tissue Involvement in Systemic Lupus Erythematosus.Current rheumatology reports · 2021Review
- The Categorization of Pain in Systemic Lupus Erythematosus.Rheumatic diseases clinics of North America · 2021Review
- Systemic lupus erythematosus: Diagnosis and clinical management.Journal of autoimmunity · 2019Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveArthritis in SLE is poorly described, and there is no objective measure for quantification of arthritis. In this pilot study, we aim to assess the utility of the Rheumatoid Arthritis MRI Scoring System (RAMRIS) for the quantification of lupus arthritis.
methodsPatients were eligible for entry into the study if they were evaluated at the Medical University of South Carolina Lupus Center and determined by their treating rheumatologist to have active hand arthritis due to SLE. Standard of care lupus activity measures were collected, along with a detailed physical exam. MRIs were obtained using standard musculoskeletal sequences with gadolinium contrast. Semiquantitative scoring of the images used the Outcome Measures in Rheumatology Clinical Trials RAMRIS system.
resultsRAMRIS demonstrates large amounts of synovitis, tenosynovitis, bone marrow oedema and erosive disease in only a minority of patients. Some patients were not scored as having any synovitis or tenosynovitis. We describe potential features of lupus arthritis that are not captured in the RAMRIS scores and may be contributing to symptoms.
conclusionLupus arthritis is an entity separate from rheumatoid arthritis and requires the development of new quantitative methods to describe and quantitate it. MRI findings suggest the inadequacy of a typical lupus musculoskeletal measure including swollen/tender joint counts to assess the level of disease activity.
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Registered trials
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