ArticleFrontiers in immunology2018
Quantitative Measurement of Naïve T Cell Association With Dendritic Cells, FRCs, and Blood Vessels in Lymph Nodes.
Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
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- Lyophilized lymph nodes for improved delivery of chimeric antigen receptor T cells.Nature materials · 2024Article
- H-Scan Discrimination for Tumor Microenvironmental Heterogeneity in Melanoma.Ultrasound in medicine & biology · 2024Article
- Enabling continuous immune cell recirculation on a microfluidic array to study immunotherapeutic interactions in a recapitulated tumour microenvironment.Lab on a chip · 2024Article
- Aging of lymphoid stromal architecture impacts immune responses.Seminars in immunology · 2023Review
- Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues.eLife · 2023Article
- A Case for Material Stiffness as a Design Parameter in Encapsulated Islet Transplantation.Tissue engineering. Part B, Reviews · 2023Review
- Profiling specific cell populations within the inflammatory tumor microenvironment by oscillating-gradient diffusion-weighted MRI.Journal for immunotherapy of cancer · 2023Article
- Unique aspects of IFN-γ/STAT1 signaling in neurons.Immunological reviews · 2022Review
- Collagen-Tannic Acid Spheroids for β-Cell Encapsulation Fabricated Using a 3D Bioprinter.Advanced materials technologies · 2022Article
- Agent-based computational modeling of glioblastoma predicts that stromal density is central to oncolytic virus efficacy.iScience · 2022Article
- A reduced 1D stochastic model of bleb-driven cell migration.Biophysical journal · 2022Article
- Analysis of cellular water content in T cells reveals a switch from slow metabolic water gain to rapid water influx prior to cell division.The Journal of biological chemistry · 2022Article
- Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy.National science review · 2022Article
- Lymph node swelling combined with temporary effector T cell retention aids T cell response in a model of adaptive immunity.Journal of the Royal Society, Interface · 2021Article
- Human Lung-Resident Macrophages Colocalize with and Provide Costimulation to PD1American journal of respiratory and critical care medicine · 2021Article
- MR cell size imaging with temporal diffusion spectroscopy.Magnetic resonance imaging · 2021Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
T cells play a vital role in eliminating pathogenic infections. To activate, naïve T cells search lymph nodes (LNs) for dendritic cells (DCs). Positioning and movement of T cells in LNs is influenced by chemokines including CCL21 as well as multiple cell types and structures in the LNs. Previous studies have suggested that T cell positioning facilitates DC colocalization leading to T:DC interaction. Despite the influence chemical signals, cells, and structures can have on naïve T cell positioning, relatively few studies have used quantitative measures to directly compare T cell interactions with key cell types. Here, we use Pearson correlation coefficient (PCC) and normalized mutual information (NMI) to quantify the extent to which naïve T cells spatially associate with DCs, fibroblastic reticular cells (FRCs), and blood vessels in LNs. We measure spatial associations in physiologically relevant regions. We find that T cells are more spatially associated with FRCs than with their ultimate targets, DCs. We also investigated the role of a key motility chemokine receptor, CCR7, on T cell colocalization with DCs. We find that CCR7 deficiency does not decrease naïve T cell association with DCs, in fact, CCR7
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.