ArticleScientific reports2018
Bundles of Brain Microtubules Generate Electrical Oscillations.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Conscious simultaneity with continuous motion: a measure-theoretic resolution of the hard problem.Frontiers in human neuroscience · 2026Article
- Oscillatory dynamics in paclitaxel-proteinoid networks.Discover molecules · 2026Article
- Electrical oscillations in microtubules.Scientific reports · 2025Article
- Electrical Oscillations in Microtubules.bioRxiv : the preprint server for biology · 2025Article
- Consciousness and spintronic coherence in microtubules.Communicative & integrative biology · 2025Article
- On the potential of microtubules for scalable quantum computation.European physical journal plus · 2025Review
- Consciousness and the Axon Initial Segment.Integrative psychological & behavioral science · 2024Article
- Emerging cancer therapies: targeting physiological networks and cellular bioelectrical differences with non-thermal systemic electromagnetic fields in the human body - a comprehensive review.Frontiers in network physiology · 2024Review
- Brain Microtubule Electrical Oscillations-Empirical Mode Decomposition Analysis.Cellular and molecular neurobiology · 2023Article
- Monte Carlo simulation and experimental validation of plant microtubules cathode in biodegradable battery.Scientific reports · 2023Article
- The electrical properties of isolated microtubules.Scientific reports · 2023Article
- There's Plenty of Room Right Here: Biological Systems as Evolved, Overloaded, Multi-Scale Machines.Biomimetics (Basel, Switzerland) · 2023Article
- Review
- Simultaneity of consciousness with physical reality: the key that unlocks the mind-matter problem.Frontiers in psychology · 2023Article
- Role of the microtubules in the electrical activity of the primary cilium of renal epithelial cells.Frontiers in molecular biosciences · 2023Article
- Electromagnetic interactions in regulations of cell behaviors and morphogenesis.Frontiers in cell and developmental biology · 2022Review
- Bio-Mimicking, Electrical Excitability Phenomena Associated With Synthetic Macromolecular Systems: A Brief Review With Connections to the Cytoskeleton and Membraneless Organelles.Frontiers in molecular neuroscience · 2022Review
- Consciousness, Cognition and the Neuronal Cytoskeleton - A New Paradigm Needed in Neuroscience.Frontiers in molecular neuroscience · 2022Article
- Electrical recordings from dendritic spines of adult mouse hippocampus and effect of the actin cytoskeleton.Frontiers in molecular neuroscience · 2022Article
- Low-energy amplitude-modulated radiofrequency electromagnetic fields as a systemic treatment for cancer: Review and proposed mechanisms of action.Frontiers in medical technology · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microtubules (MTs) are long cylindrical structures of the cytoskeleton that control cell division, intracellular transport, and the shape of cells. MTs also form bundles, which are particularly prominent in neurons, where they help define axons and dendrites. MTs are bio-electrochemical transistors that form nonlinear electrical transmission lines. However, the electrical properties of most MT structures remain largely unknown. Here we show that bundles of brain MTs spontaneously generate electrical oscillations and bursts of electrical activity similar to action potentials. Under intracellular-like conditions, voltage-clamped MT bundles displayed electrical oscillations with a prominent fundamental frequency at 39 Hz that progressed through various periodic regimes. The electrical oscillations represented, in average, a 258% change in the ionic conductance of the MT structures. Interestingly, voltage-clamped membrane-permeabilized neurites of cultured mouse hippocampal neurons were also capable of both, generating electrical oscillations, and conducting the electrical signals along the length of the structure. Our findings indicate that electrical oscillations are an intrinsic property of brain MT bundles, which may have important implications in the control of various neuronal functions, including the gating and regulation of cytoskeleton-regulated excitable ion channels and electrical activity that may aid and extend to higher brain functions such as memory and consciousness.
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