ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018
Striatal activity correlates with stimulant-like effects of alcohol in healthy volunteers.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Ventral prefrontal network response to alcohol in young adults with bipolar disorder: a within-subject randomized placebo-controlled alcohol administration study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Stimulant-like subjective effects of alcohol are not related to resting-state connectivity in healthy men.Cerebral cortex (New York, N.Y. : 1991) · 2023Trial
- Neural correlates of inhibitory control are associated with stimulant-like effects of alcohol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Striatal activation to monetary reward is associated with alcohol reward sensitivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Poor inhibitory control is associated with greater stimulation and less sedation following alcohol.Psychopharmacology · 2020Trial
- Dorsal striatal circuit mechanisms contributing to astrocyte modulation of alcohol-related behaviors.bioRxiv : the preprint server for biology · 2026Article
- Neural underpinnings of expecting alcohol: Placebo alcohol administration alters nucleus accumbens resting state functional connectivity.Behavioural brain research · 2023Article
- Ghrelin Predicts Stimulant and Sedative Effects of Alcohol in Heavy Drinkers.Alcohol and alcoholism (Oxford, Oxfordshire) · 2023Article
- Haven't lost the positive feeling: a dose-response, oral alcohol challenge study in drinkers with alcohol use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Patterns of functional connectivity alterations induced by alcohol reflect somatostatin interneuron expression in the human cerebral cortex.Scientific reports · 2022Article
- Interoception and alcohol: Mechanisms, networks, and implications.Neuropharmacology · 2021Review
- Acute effects of alcohol on resting-state functional connectivity in healthy young men.Addictive behaviors · 2021Article
- Subjective Effects of Alcohol Predict Alcohol Choice in Social Drinkers.Alcoholism, clinical and experimental research · 2020Article
- The Feasibility, Tolerability, and Safety of Administering a Very High Alcohol Dose to Drinkers with Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2020Article
- Alcohol Cue-Induced Ventral Striatum Activity Predicts Subsequent Alcohol Self-Administration.Alcoholism, clinical and experimental research · 2020Article
- A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors.Cell reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Individuals who experience greater stimulation and less sedation from alcohol are at increased risk for alcohol-related problems. However, little is known regarding the neurobiological mechanisms underlying subjective response to alcohol. The current study examined the degree to which alcohol-induced brain activation correlates with ratings of stimulation and sedation, using a within-subjects, double-blind, placebo-controlled design. Participants (N = 34 healthy adults with no history of alcohol use disorder) completed three sessions: a calibration session to determine the duration of infusion needed to bring the breath alcohol to 80 mg/dl for each subject, and two counterbalanced fMRI sessions with placebo and alcohol administration. During the fMRI sessions, participants underwent 50 min scans, which included a 10 min baseline period, the IV infusion period needed to bring breath alcohol concentration (BrAC) to a peak 80 mg/dl (on the alcohol session), followed by a post-peak decline period. Participants rated their subjective stimulation and sedation at regular intervals throughout the scan. A priori VOI analyses showed that the time course of stimulation correlated with BOLD signal in the striatum. The time course of sedation did not correlate with BOLD signal in any VOIs. There were no correlations in primary visual cortex, which served as a control. These findings are the first to show that alcohol effects in the striatum are linked to the positive, stimulant-like effects of the drug and advance our understanding of the neurobiological mechanisms underlying individual differences in subjective responses to alcohol, and more broadly, risk for alcohol use disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.