Evidence map›Paper›PMID 30093612›Full record

ArticleNature communications2018

Identification of nine new susceptibility loci for endometrial cancer.

Tracy A O'Mara, Dylan M Glubb, Frederic Amant, Daniela Annibali, Katie Ashton, John Attia, Paul L Auer, Matthias W Beckmann, Amanda Black, Manjeet K Bolla and 115 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 10 pooled it
7.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

176 citing papers in PubMed, 10 syntheses or guidelines pooled it, 321 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Observational

116 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

125 authors at 20 institutions in 12 countries.

Tracy A O'MaraDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, QLD, Australia. Tracy.OMara@qimrberghofer.edu.au.ORCID http://orcid.org/0000-0002-5436-3232
Dylan M GlubbDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, QLD, Australia.ORCID http://orcid.org/0000-0002-2184-7708
Frederic AmantDepartment of Obstetrics and Gynecology, University Hospitals KU Leuven, University of Leuven, Division of Gynecologic Oncology, Leuven, 3000, Belgium.
Daniela AnnibaliDepartment of Obstetrics and Gynecology, University Hospitals KU Leuven, University of Leuven, Division of Gynecologic Oncology, Leuven, 3000, Belgium.ORCID http://orcid.org/0000-0001-8413-7669
Katie AshtonJohn Hunter Hospital, Hunter Medical Research Institute, Newcastle, 2305, NSW, Australia.
John AttiaJohn Hunter Hospital, Hunter Medical Research Institute, Newcastle, 2305, NSW, Australia.ORCID http://orcid.org/0000-0001-9800-1308
Paul L AuerCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, 98109, WA, USA.
Matthias W BeckmannDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center ER-EMN, Erlangen, 91054, Germany.
Amanda BlackNational Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, 20892, MD, USA.
Manjeet K BollaDepartment of Public Health and Primary Care, University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, CB1 8RN, UK.
Hiltrud BrauchDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, 70376, Germany.ORCID http://orcid.org/0000-0001-7531-2736
Hermann BrennerGerman Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, 69120, Germany.
Louise BrintonNational Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, 20892, MD, USA.
Daniel D BuchananDepartment of Clinical Pathology, The University of Melbourne, Melbourne, 3010, VIC, Australia.ORCID http://orcid.org/0000-0003-2225-6675
Barbara BurwinkelDepartment of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, 69120, Germany.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
Stephen J ChanockNational Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, 20892, MD, USA.
Chu ChenEpidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, 98109, WA, USA.
Maxine M ChenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, USA.
Timothy H T ChengUniversity of Oxford, Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, Oxford, OX3 7BN, UK.
Christine L ClarkeUniversity of Sydney, Westmead Institute for Medical Research, Sydney, 2145, NSW, Australia.
Mark ClendenningDepartment of Clinical Pathology, The University of Melbourne, Melbourne, 3010, VIC, Australia.
Linda S CookUniversity of New Mexico, University of New Mexico Health Sciences Center, Albuquerque, 87131, NM, USA.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, 55905, MN, USA.
Angela CoxDepartment of Oncology and Metabolism, University of Sheffield, Sheffield Institute for Nucleic Acids (SInFoNiA), Sheffield, S10 2TN, UK.
Marta Crous-BousDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, USA.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 171 65, Sweden.
Felix DayUniversity of Cambridge, MRC Epidemiology Unit, School of Clinical Medicine, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0003-3789-7651
Joe DennisDepartment of Public Health and Primary Care, University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, CB1 8RN, UK.ORCID http://orcid.org/0000-0003-4591-1214
Jeroen DepreeuwDepartment of Obstetrics and Gynecology, University Hospitals KU Leuven, University of Leuven, Division of Gynecologic Oncology, Leuven, 3000, Belgium.
Jennifer Anne DohertyCancer Research Huntsman Cancer Institute Department of Population Health Sciences, University of Utah, Salt Lake City, 84112, UT, USA.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover, 30625, Germany.
Sean C DowdyDepartment of Obstetrics and Gynecology, Mayo Clinic, Division of Gynecologic Oncology, Rochester, 55905, MN, USA.
Matthias DürstDepartment of Gynaecology, Jena University Hospital - Friedrich Schiller University, Jena, 07743, Germany.
Arif B EkiciFriedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Institute of Human Genetics, University Hospital Erlangen, Erlangen, 91054, Germany.
Peter A FaschingDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center ER-EMN, Erlangen, 91054, Germany.ORCID http://orcid.org/0000-0003-4885-8471
Brooke L FridleyDepartment of Biostatistics, Kansas University Medical Center, Kansas City, 66160, KS, USA.
Christine M FriedenreichDepartment of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, T2N 4N2, AB, Canada.ORCID http://orcid.org/0000-0002-4783-1966
Lin FritschiCurtin University, School of Public Health, Perth, 6102, WA, Australia.
Jenny FungUniversity of Queensland, Institute for Molecular Bioscience, Brisbane, 4072, QLD, Australia.
Montserrat García-ClosasNational Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, 20892, MD, USA.
Mia M GaudetAmerican Cancer Society, Epidemiology Research Program, Atlanta, 30303, GA, USA.
Graham G GilesThe University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, 3010, VIC, Australia.
Ellen L GoodeDepartment of Health Science Research, Mayo Clinic, Division of Epidemiology, Rochester, 55905, MN, USA.
Maggie GormanUniversity of Oxford, Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, Oxford, OX3 7BN, UK.
Christopher A HaimanDepartment of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, 90033, CA, USA.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 171 65, Sweden.
Susan E HankisonDepartment of Medicine, Harvard Medical School, Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, 02115, MA, USA.
Catherine S HealeyDepartment of Oncology, University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, CB1 8RN, UK.
Alexander HeinDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center ER-EMN, Erlangen, 91054, Germany.ORCID http://orcid.org/0000-0003-2601-3398
Peter HillemannsGynaecology Research Unit, Hannover Medical School, Hannover, 30625, Germany.
Shirley HodgsonDepartment of Clinical Genetics, St George's, University of London, London, SW17 0RE, UK.
Erling A HoivikDepartment of Clinical Science, University of Bergen, Centre for Cancer Biomarkers, Bergen, 5020, Norway.
Elizabeth G HollidayJohn Hunter Hospital, Hunter Medical Research Institute, Newcastle, 2305, NSW, Australia.
John L HopperThe University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, 3010, VIC, Australia.
David J HunterDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, USA.
Angela JonesUniversity of Oxford, Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, Oxford, OX3 7BN, UK.
Camilla KrakstadDepartment of Clinical Science, University of Bergen, Centre for Cancer Biomarkers, Bergen, 5020, Norway.
Vessela N KristensenDepartment of Cancer Genetics, Oslo University Hospital, Radiumhospitalet, Institute for Cancer Research, Oslo, 0379, Norway.
Diether LambrechtsDepartment of Human Genetics, University of Leuven, Laboratory for Translational Genetics, Leuven, 3000, Belgium.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, 96813, HI, USA.
Xiaolin LiangDepartment of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, 10065, NY, USA.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, 171 76, Sweden.
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center-Oncology Institute, Warsaw, 02-034, Poland.
Jirong LongDepartment of Medicine, Vanderbilt University School of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Nashville, 37232, TN, USA.
Lingeng LuChronic Disease Epidemiology, Yale School of Public Health, New Haven, 06510, CT, USA.ORCID http://orcid.org/0000-0001-9871-0809
Anthony M MaglioccoDepartment of Anatomic Pathology, Moffitt Cancer Center and Research Institute, Tampa, 33612, FL, USA.
Lynn MartinUniversity of Birmingham, Institute of Cancer and Genomic Sciences, Birmingham, B15 2TT, UK.ORCID http://orcid.org/0000-0003-3962-389X
Mark McEvoyUniversity of Newcastle, Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, Callaghan, 2308, NSW, Australia.
Alfons MeindlDepartment of Gynecology and Obstetrics, Ludwig-Maximilians University of Munich, Munich, 80336, Germany.
Kyriaki MichailidouDepartment of Public Health and Primary Care, University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, CB1 8RN, UK.ORCID http://orcid.org/0000-0001-7065-1237
Roger L MilneThe University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, 3010, VIC, Australia.ORCID http://orcid.org/0000-0001-5764-7268
Miriam MintsDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden.
Grant W MontgomeryDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, QLD, Australia.ORCID http://orcid.org/0000-0002-4140-8139
Rami NassirDepartment of Biochemistry and Molecular Medicine, University of California Davis, Davis, 95817, CA, USA.
Håkan OlssonDepartment of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, 222 42, Sweden.
Irene OrlowDepartment of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, 10065, NY, USA.
Geoffrey OttonUniversity of Newcastle, School of Medicine and Public Health, Callaghan, 2308, NSW, Australia.
Claire PallesUniversity of Oxford, Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, Oxford, OX3 7BN, UK.
John R B PerryUniversity of Cambridge, MRC Epidemiology Unit, School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Julian PetoDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Loreall PoolerDepartment of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, 90033, CA, USA.
Jennifer PrescottDepartment of Medicine, Harvard Medical School, Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, 02115, MA, USA.
Tony ProiettoUniversity of Newcastle, School of Medicine and Public Health, Callaghan, 2308, NSW, Australia.
Timothy R RebbeckHarvard T.H. Chan School of Public Health, Boston, 02115, MA, USA.
Harvey A RischChronic Disease Epidemiology, Yale School of Public Health, New Haven, 06510, CT, USA.
Peter A W RogersDepartment of Obstetrics and Gynaecology, University of Melbourne, Royal Women's Hospital, Gynaecology Research Centre, Parkville, 3052, VIC, Australia.
Matthias RübnerDepartment of Gynaecology and Obstetrics, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Erlangen, 91054, Germany.
Ingo RunnebaumDepartment of Gynaecology, Jena University Hospital - Friedrich Schiller University, Jena, 07743, Germany.
Carlotta SacerdoteCenter for Cancer Prevention (CPO-Peimonte), Turin, 10126, Italy.
Gloria E SartoDepartment of Obstetrics and Gynecology, University of Wisconsin, School of Medicine and Public Health, Madison, 53715, WI, USA.
Fredrick SchumacherDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, 44106, OH, USA.
Rodney J ScottJohn Hunter Hospital, Hunter Medical Research Institute, Newcastle, 2305, NSW, Australia.
V Wendy SetiawanDepartment of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, 90033, CA, USA.
Mitul ShahDepartment of Oncology, University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, CB1 8RN, UK.
Xin ShengDepartment of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, 90033, CA, USA.
Xiao-Ou ShuDepartment of Medicine, Vanderbilt University School of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Nashville, 37232, TN, USA.
Melissa C SoutheyDepartment of Clinical Pathology, The University of Melbourne, Melbourne, 3010, VIC, Australia.
Anthony J SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SM2 5NG, UK.
Emma ThamDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, 171 76, Sweden.
Jone TrovikDepartment of Clinical Science, University of Bergen, Centre for Cancer Biomarkers, Bergen, 5020, Norway.
Constance TurmanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, USA.
Jonathan P TyrerDepartment of Oncology, University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, CB1 8RN, UK.
Celine VachonDepartment of Health Sciences Research, Mayo Clinic, Rochester, 55905, MN, USA.
David VanDen BergDepartment of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, 90033, CA, USA.
Adriaan VandersticheleDepartment of Obstetrics and Gynaecology, University Hospitals Leuven, Division of Gynecologic Oncology, Leuven Cancer Institute, Leuven, 3000, Belgium.
Zhaoming WangNational Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, 20892, MD, USA.
Penelope M WebbDepartment of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, 4006, QLD, Australia.ORCID http://orcid.org/0000-0003-0733-5930
Nicolas WentzensenNational Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, 20892, MD, USA.
Henrica M J WernerDepartment of Clinical Science, University of Bergen, Centre for Cancer Biomarkers, Bergen, 5020, Norway.
Stacey J WinhamDepartment of Health Science Research, Mayo Clinic, Division of Biomedical Statistics and Informatics, Rochester, 55905, MN, USA.
Alicja WolkDepartment of Environmental Medicine, Karolinska Institutet, Division of Nutritional Epidemiology, Stockholm, 171 77, Sweden.ORCID http://orcid.org/0000-0001-7387-6845
Lucy XiaDepartment of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, 90033, CA, USA.
Yong-Bing XiangDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, State Key Laboratory of Oncogene and Related Genes, Shanghai, China.
Hannah P YangNational Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, 20892, MD, USA.
Herbert YuEpidemiology Program, University of Hawaii Cancer Center, Honolulu, 96813, HI, USA.ORCID http://orcid.org/0000-0003-3950-4815
Wei ZhengDepartment of Medicine, Vanderbilt University School of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Nashville, 37232, TN, USA.ORCID http://orcid.org/0000-0003-1226-070X
Paul D P PharoahDepartment of Public Health and Primary Care, University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, CB1 8RN, UK.ORCID http://orcid.org/0000-0001-8494-732X
Alison M DunningDepartment of Oncology, University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, CB1 8RN, UK.
Peter KraftDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, USA.
Immaculata De VivoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, USA.
Ian TomlinsonUniversity of Oxford, Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, Oxford, OX3 7BN, UK.ORCID http://orcid.org/0000-0003-3037-1470
Douglas F EastonDepartment of Public Health and Primary Care, University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, CB1 8RN, UK.ORCID http://orcid.org/0000-0003-2444-3247
Amanda B SpurdleDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, QLD, Australia. Amanda.Spurdle@qimrberghofer.edu.au.
Deborah J ThompsonDepartment of Public Health and Primary Care, University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, CB1 8RN, UK. djt25@medschl.cam.ac.uk.ORCID http://orcid.org/0000-0003-1465-5799
University of Cambridge · GBKarolinska Institutet · SENational Cancer Institute · USUniversity of Southern California · USCentre for Human Genetics · GBHarvard University · USThe University of Melbourne · AUBrigham and Women's Hospital · USHaukeland University Hospital · NOJohn Hunter Hospital · AUQIMR Berghofer Medical Research Institute · AUUniversitätsklinikum Erlangen · DEGerman Cancer Research Center · DEKU Leuven · BEMayo Clinic in Florida · USUniversity of Newcastle Australia · AUVanderbilt University · USAlberta Health Services · CAFred Hutch Cancer Center · USInstitute of Cancer Research · GB

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI ELLEN L. GOODE · 2009 to 2026
$37.0M
CALIFORNIA TEACHERS STUDYR01CA077398 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1998 to 2014
$29.7M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Epidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4M
Ovarian cancer GWAS discovery, expansion and replication (N2 - Project #1)U19CA148112 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI SELLERS, THOMAS A · 2010 to 2014
$10.2M
Shanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9M
Cancer Research UK 10118Cancer Research UK 16459Cancer Research UK 16565Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_12015/2NCI NIH HHS K05 CA092002NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA015083NCI NIH HHS P50 CA136393NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA058598NCI NIH HHS R01 CA077398NCI NIH HHS R01 CA082838NCI NIH HHS R01 CA087538NCI NIH HHS R01 CA091019NCI NIH HHS R01 CA098346NCI NIH HHS R01 CA105212NCI NIH HHS R01 CA122443NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA134958NCI NIH HHS R01 CA149429NCI NIH HHS R03 CA080636NCI NIH HHS R03 CA128008NCI NIH HHS R37 CA054281NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS UM1 CA182910NCI NIH HHS UM1 CA186107NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNIA NIH HHS HHSN271201100004CNICHD NIH HHS N01 HD023166Wellcome TrustWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.

Indexed as

Genetic Predisposition to DiseaseAllelesBiomarkers, TumorChromatinEndometrial NeoplasmsFemaleGene FrequencyGenome-Wide Association StudyGenotypeHumansPolymorphism, Single NucleotideQuantitative Trait LociRisk FactorsSignal TransductionBiomarkers, TumorChromatin

Identifiers

PMID30093612
PMCPMC6085317
OpenAlexW2886497950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.