Evidence map›Paper›PMID 30093599›Full record

ArticleScience (New York, N.Y.)2018

Apoptosis propagates through the cytoplasm as trigger waves.

Xianrui Cheng, James E Ferrell

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 196 citations in OpenAlex.

  1. Article
  2. Review
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  7. Review
  8. Article
  9. Geometrical compartmentalization of trigger waves.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Review
  11. The Dual Role ofBiology · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. The complexities of cell death mechanisms: a new perspective in systemic sclerosis therapy.Apoptosis : an international journal on programmed cell death · 2025
    Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Veterinary sciences · 2024
    Article

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xianrui ChengDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA.ORCID 0000-0002-5258-7590
James E FerrellDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA. james.ferrell@stanford.edu.ORCID 0000-0003-4767-3926
Stanford University · US

Funding

TRAINING & OUTREACH COREP50GM107615 · NIGMS · STANFORD UNIVERSITY · PI COVERT, MARKUS W · 2013 to 2017
$10.9M
Trigger waves and coupled oscillations in the embryonic cell cycleR01GM110564 · NIGMS · STANFORD UNIVERSITY · PI FERRELL, JAMES E. · 2015 to 2018
$1.3M
NIGMS NIH HHS P50 GM107615NIGMS NIH HHS R01 GM110564
6 · The paper itself

Abstract

Apoptosis is an evolutionarily conserved form of programmed cell death critical for development and tissue homeostasis in animals. The apoptotic control network includes several positive feedback loops that may allow apoptosis to spread through the cytoplasm in self-regenerating trigger waves. We tested this possibility in cell-free

Indexed as

Signal TransductionAnimalsApoptosisCell-Free SystemCytoplasmOocytesXenopus laevis

Identifiers

PMID30093599
PMCPMC6263143
OpenAlexW2885028350

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.