ArticleScience (New York, N.Y.)2018
Lacteal junction zippering protects against diet-induced obesity.
Open access · greenAbstract read
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Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers.
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162citing papers in PubMed
8.1field-weighted citation impact, top 1% of its field
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Who cites it
162 citing papers in PubMed, 227 citations in OpenAlex.
- Article
- Cardiac lymphatic dysfunction and repair in cardiovascular disease.Nature reviews. Cardiology · 2026Review
- Bidirectional crosstalk between obesity and the lymphatic system: a novel pathway in obesity pathogenesis and treatment.International journal of obesity (2005) · 2026Review
- Toll-like receptor 2 impacts small intestinal villus capillarization through epithelial dual oxidase 2.Redox biology · 2026Article
- Plasma neuropilin-1 is associated with a favorable lipid profile and insulin sensitivity in a population-based sample of 50-year-old individuals.Scientific reports · 2026Article
- Lymphatic Endothelial Cells in Health and Disease.MedComm · 2026Review
- Quantification of Lacteal Contractility by Live Intravital Imaging.Microcirculation (New York, N.Y. : 1994) · 2026Article
- Endothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs.Angiogenesis · 2026Article
- Eosinophils promote a second wave of postnatal smooth muscle differentiation in intestinal villi.The Journal of cell biology · 2026Article
- Dysfunctional adipose tissue-lymphatic crosstalk in obesity.Nature reviews. Endocrinology · 2026Review
- GPR182 and the reframing of lacteal chylomicron uptake.The Journal of clinical investigation · 2026Article
- GPR182 is a lipoprotein receptor for dietary fat absorption.The Journal of clinical investigation · 2026Article
- Increased Vascular Endothelial Growth Factor Receptor 2 Levels Are Associated With a Higher Occurrence of Coronary Artery Disease in Patients With Obstructive Sleep Apnea.Reviews in cardiovascular medicine · 2026Article
- Lymphatics-on-a-chip microphysiological system: engineering lymphatic structure and functionLab on a chip · 2026Review
- Fish oil reduces intestinal fat absorption by promoting lacteal junction zippering via GPR120-VEGFR3-MLCK pathway.Journal of advanced research · 2026Article
- Transcriptomics- and 3D imaging-based characterization of the lymphatic vasculature in human skin.The Journal of experimental medicine · 2026Article
- Lymphatic dysfunction and impaired interstitial clearance in sarcopenic obesity: a hypothesis-generating review.Frontiers in endocrinology · 2026Review
- Lung Lymphatics in Edema, Inflammation, and Thrombosis.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- APOA1 binding protein promotes lymphatic cell fate and lymphangiogenesis by relieving caveolae-mediated inhibition of VEGFR3 signaling.Nature communications · 2025Article
- Intestinal lymphatic vasculature is functionally adapted to different drainage regions and is altered by helminth infection.The Journal of experimental medicine · 2025Article
102 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 3 countries.
Feng ZhangCardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510-3221, USA.ORCID 0000-0002-6103-1498
Georgia ZarkadaCardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510-3221, USA.ORCID 0000-0001-5036-1451
Jinah HanCardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510-3221, USA.
Jinyu LiCardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510-3221, USA.ORCID 0000-0002-7693-012X
Alexandre DubracCardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510-3221, USA.ORCID 0000-0002-3829-2577
Roxana OlaCardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510-3221, USA.ORCID 0000-0001-8419-0881
Gael GenetCardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510-3221, USA.
Kevin BoyéCardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510-3221, USA.ORCID 0000-0002-5749-959X
Pauline MichonCardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510-3221, USA.
Steffen E KünzelCardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510-3221, USA.ORCID 0000-0002-6466-168X
Joao Paulo CamporezDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Abhishek K SinghDepartments of Comparative Medicine and Pathology, Vascular Biology and Therapeutics Program and Integrative Cell Signaling and Neurobiology of Metabolism Program, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4474-1367
Guo-Hua FongDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT, 06030-3501, USA.
Michael SimonsCardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510-3221, USA.ORCID 0000-0003-0348-7734
Patrick TsoDepartment of Pathology and Laboratory Medicine, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH 45237-0507, USA.
Carlos Fernández-HernandoDepartments of Comparative Medicine and Pathology, Vascular Biology and Therapeutics Program and Integrative Cell Signaling and Neurobiology of Metabolism Program, Yale University School of Medicine, New Haven, CT, USA.
Gerald I ShulmanDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-1529-5668
William C SessaDepartment of Pharmacology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5759-1938
Anne EichmannCardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510-3221, USA. anne.eichmann@yale.edu.ORCID 0000-0001-5563-210X
Yale University · USInserm · FRTransylvania University of Brașov · ROUConn Health · USUniversity of Cincinnati · US
Funding
Surgery / Physiology CoreP01HL107205 · NHLBI · YALE UNIVERSITY · PI SIMONS, MICHAEL · 2012 to 2022
$18.8MVascular Training GrantT32HL007950 · NHLBI · YALE UNIVERSITY · PI JEFFREY R. BENDER, Daniel Greif · 2000 to 2026
$9.6MIMMUNOHEMATOLOGY/TRANSFUSION MEDICINE RESEARCH TRAININGT32HL007974 · NHLBI · YALE UNIVERSITY · PI JEANNE E HENDRICKSON, Diane S Krause · 2001 to 2026
$8.1MAngiogensis and ischemiaR01HL053793 · NHLBI · YALE UNIVERSITY · PI SIMONS, MICHAEL · 1996 to 2017
$7.3MYale Core Grant for Vision ResearchP30EY026878 · NEI · YALE UNIVERSITY · PI In-Jung Kim · 2016 to 2026
$7.1MEndothelial-to-mesenchyma transition and atherosclerosisR01HL135582 · NHLBI · YALE UNIVERSITY · PI SCHWARTZ, MARTIN A, SIMONS, MICHAEL · 2017 to 2024
$6.6MLipid profile, lipoprotein and apolipoprotein composition, and intestinal fat absorption efficiency in germ-free and conventional miceU2CDK059630 · NIDDK · UNIVERSITY OF CINCINNATI · PI LIU, MIN · 2016 to 2021
$4.9MInsights into the Molecular and Cellular Mechanisms governing Endothelial FunctionR35HL139945 · NHLBI · YALE UNIVERSITY · PI SESSA, WILLIAM C · 2018 to 2021
$4.3MTargeting endothelial migration to prevent neovascularizationR01HL125811 · NHLBI · YALE UNIVERSITY · PI EICHMANN, ANNE CHRISTINE · 2015 to 2025
$4.1MNovel approaches to manipulate sprouting angiogenesisR01EY025979 · NEI · YALE UNIVERSITY · PI EICHMANN, ANNE CHRISTINE · 2015 to 2019
$1.9MNovel approached to prevent diet-induced obesity via lacteal junctionsR01DK120373 · NIDDK · YALE UNIVERSITY · PI EICHMANN, ANNE CHRISTINE · 2019 to 2022
$1.5MNEI NIH HHS P30 EY026878NEI NIH HHS R01 EY025979NHLBI NIH HHS P01 HL107205NHLBI NIH HHS R01 HL053793NHLBI NIH HHS R01 HL125811NHLBI NIH HHS R01 HL135582NHLBI NIH HHS R35 HL139945NHLBI NIH HHS T32 HL007950NHLBI NIH HHS T32 HL007974NIDDK NIH HHS R01 DK120373NIDDK NIH HHS U2C DK059630
Abstract
Excess dietary lipid uptake causes obesity, a major global health problem. Enterocyte-absorbed lipids are packaged into chylomicrons, which enter the bloodstream through intestinal lymphatic vessels called lacteals. Here, we show that preventing lacteal chylomicron uptake by inducible endothelial genetic deletion of
Indexed as
AnimalsAntigens, CDCadherin 5CadherinsChylomicronsDietary FatsDiet, High-FatEnterocytesGene DeletionIntestinal AbsorptionMaleMiceMice, KnockoutNeuropilin-1ObesitySignal TransductionAntigens, CDCadherin 5CadherinsChylomicronsDietary FatsFlt1 protein, mouseKdr protein, mouseNeuropilin-1Vascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth Factor Receptor-2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.