Evidence map›Paper›PMID 30093596›Full record

ArticleScience (New York, N.Y.)2018

Ancient convergent losses of

Wynn K Meyer, Jerrica Jamison, Rebecca Richter, Stacy E Woods, Raghavendran Partha, Amanda Kowalczyk, Charles Kronk, Maria Chikina, Robert K Bonde, Daniel E Crocker and 5 more

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. The genetic foundations of convergent traits.Nature reviews. Genetics · 2026
    Review
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  17. Paraoxonase 1 and atherosclerosis.Frontiers in cardiovascular medicine · 2023
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Wynn K MeyerDepartment of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-7978-3877
Jerrica JamisonDietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-0354-6992
Rebecca RichterDivision of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA.
Stacy E WoodsBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-8412-1149
Raghavendran ParthaDepartment of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-7900-4375
Amanda KowalczykDepartment of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-9061-1336
Charles KronkDietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-8397-8810
Maria ChikinaDepartment of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Robert K BondeWetland and Aquatic Research Center, U.S. Geological Survey, Gainesville, FL, USA.
Daniel E CrockerDepartment of Biology, Sonoma State University, Rohnert Park, CA, USA.
Joseph GaspardPittsburgh Zoo and PPG Aquarium, Pittsburgh, PA, USA.ORCID 0000-0002-1084-3437
Janet M LanyonSchool of Biological Sciences, The University of Queensland, St. Lucia, QLD 4072, Australia.
Judit MarsillachDivision of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3061-6266
Clement E FurlongDivision of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6489-7211
Nathan L ClarkDepartment of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA. nclark@pitt.edu.ORCID 0000-0003-0006-8374
University of Pittsburgh · USUniversity of Washington Medical Center · USJohns Hopkins University · USSonoma State University · USThe University of Queensland · AUUnited States Geological Survey · USUniversity of Washington · US

Funding

TrainingU54HG008540 · NHGRI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAHAR, IVET, BERG, JEREMY M · 2014 to 2018
$12.8M
Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI GURALNICK, MICHAEL J · 2014 to 2019
$7.9M
Integrated Interdisciplinary, inter-university PhD Program Computational Biology (T32)T32EB009403 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAHAR, IVET, BAR-JOSEPH, ZIV · 2009 to 2023
$4.4M
Title: Functional Annotation of Genomes via Phenotypic Convergence within Large Multi-species AlignmentsR01HG009299 · NHGRI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Maria D Chikina, Nathaniel L Clark · 2017 to 2026
$4.1M
NHGRI NIH HHS R01 HG009299NHGRI NIH HHS U54 HG008540NIBIB NIH HHS T32 EB009403NICHD NIH HHS U54 HD083091
6 · The paper itself

Abstract

Mammals diversified by colonizing drastically different environments, with each transition yielding numerous molecular changes, including losses of protein function. Though not initially deleterious, these losses could subsequently carry deleterious pleiotropic consequences. We have used phylogenetic methods to identify convergent functional losses across independent marine mammal lineages. In one extreme case,

Indexed as

CetaceaEvolution, MolecularLipid MetabolismMetabolic Detoxication, Phase IAdaptation, BiologicalAnimalsAryldialkylphosphataseEnvironmental ExposureGenetic FitnessLipoproteins, HDLLipoproteins, LDLOrganophosphorus CompoundsOxidation-ReductionPhylogenyRiskSelection, GeneticAryldialkylphosphataseLipoproteins, HDLLipoproteins, LDLOrganophosphorus Compounds

Identifiers

PMID30093596
PMCPMC6317340
OpenAlexW2885999244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.