Evidence map›Paper›PMID 30093573›Full record

ArticleThe European respiratory journal2018

The vitamin D binding protein axis modifies disease severity in lymphangioleiomyomatosis.

Suzanne Miller, Clare Coveney, Janice Johnson, Aliki-Eleni Farmaki, Nishant Gupta, Martin D Tobin, Louise V Wain, Francis X McCormack, David J Boocock, Simon R Johnson

Open access · bronzeAbstract read
In one paragraph

Article in The European respiratory journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Lymphangioleiomyomatosis: circulating levels of FGF23 and pulmonary diffusion.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2023
    Article
  7. Article
  8. Article
  9. Lymphangioleiomyomatosis: a clinical review.Breathe (Sheffield, England) · 2020
    Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Suzanne MillerDivision of Respiratory Medicine, University of Nottingham and National Institute for Health Research, Respiratory Biomedical Research Centre, Nottingham, UK.
Clare CoveneyJohn van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, UK.
Janice JohnsonDivision of Respiratory Medicine, University of Nottingham and National Institute for Health Research, Respiratory Biomedical Research Centre, Nottingham, UK.
Aliki-Eleni FarmakiDept of Health Sciences, College of Life Sciences, University of Leicester, Leicester, UK.
Nishant GuptaDivision of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati, Cincinnati, OH, USA.
Martin D TobinDept of Health Sciences, College of Life Sciences, University of Leicester, Leicester, UK.
Louise V WainDept of Health Sciences, College of Life Sciences, University of Leicester, Leicester, UK.
Francis X McCormackDivision of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati, Cincinnati, OH, USA.
David J BoocockJohn van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, UK.ORCID 0000-0002-7333-3549
Simon R JohnsonDivision of Respiratory Medicine, University of Nottingham and National Institute for Health Research, Respiratory Biomedical Research Centre, Nottingham, UK.
University of Leicester · GBUniversity of Nottingham · GBNottingham Trent University · GBUniversity of Cincinnati · US

Funding

Medical Research Council MR/N005953/1Wellcome TrustWellcome Trust WT 202849/Z/16/Z
6 · The paper itself

Abstract

Lymphangioleiomyomatosis (LAM) is a rare disease of women. Decline in lung function is variable, making appropriate targeting of therapy difficult. We used unbiased serum proteomics to identify markers associated with outcome in LAM.101 women with LAM and 22 healthy controls were recruited from the National Centre for LAM in the UK. 152 DNA and serum samples with linked lung function and outcome data were obtained from patients in the National Heart, Lung and Blood Institute LAM Registry in the USA. Proteomic analysis was performed on a discovery cohort of 50 LAM and 20 control serum samples using a SCIEX SWATH mass spectrometric workflow. Protein levels were quantitated by ELISA and single nucleotide polymorphisms in

Indexed as

Polymorphism, Single NucleotideAdultCase-Control StudiesFemaleHaplotypesHumansLungLung NeoplasmsLung TransplantationLymphangioleiomyomatosisMiddle AgedProteomicsSurvival AnalysisTomography, X-Ray ComputedUnited KingdomUnited StatesVitamin D-Binding Protein

Identifiers

PMID30093573
PMCPMC6214577
OpenAlexW2887267381

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.