Evidence map›Paper›PMID 30093555›Full record

ArticleDevelopment (Cambridge, England)2018

Gli3 controls the onset of cortical neurogenesis by regulating the radial glial cell cycle through

Kerstin Hasenpusch-Theil, Stephen West, Alexandra Kelman, Zrinko Kozic, Sophie Horrocks, Andrew P McMahon, David J Price, John O Mason, Thomas Theil

Open access · hybridAbstract read
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Association BetweenGenes · 2026
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  13. Control of GThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
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  19. The Neocortical Progenitor Specification Program Is Established through Combined Modulation of SHH and FGF Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Kerstin Hasenpusch-TheilCentre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK.
Stephen WestCentre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK.
Alexandra KelmanCentre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK.
Zrinko KozicCentre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK.
Sophie HorrocksCentre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK.
Andrew P McMahonDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad-CIRM Center for Regenerative Medicine and Stem Cell Research, W.M. Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
David J PriceCentre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK.
John O MasonCentre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK.
Thomas TheilCentre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK thomas.theil@ed.ac.uk.ORCID 0000-0001-6590-8309
Discovery Centre · CAUniversity of Southern California · US

Funding

Medical Research Council MR/K013750/1
6 · The paper itself

Abstract

The cerebral cortex contains an enormous number of neurons, allowing it to perform highly complex neural tasks. Understanding how these neurons develop at the correct time and place and in accurate numbers constitutes a major challenge. Here, we demonstrate a novel role for Gli3, a key regulator of cortical development, in cortical neurogenesis. We show that the onset of neuron formation is delayed in

Indexed as

AnimalsCell CycleCerebral CortexCyclin-Dependent Kinase 6FemaleGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicMiceMice, TransgenicNerve Tissue ProteinsNeurogenesisNeurogliaZinc Finger Protein Gli3Cdk6 protein, mouseCyclin-Dependent Kinase 6Gli3 protein, mouseNerve Tissue ProteinsZinc Finger Protein Gli3Cdk6Cell cycleGli3MouseNeurogenesis

Identifiers

PMID30093555
PMCPMC6141774
OpenAlexW2886605383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.