Evidence map›Paper›PMID 30093545›Full record

ArticleHeart (British Cardiac Society)2019

Right ventricle to pulmonary artery coupling in patients undergoing transcatheter aortic valve implantation.

Ibrahim Sultan, Arturo Cardounel, Islam Abdelkarim, Arman Kilic, Andrew D Althouse, Michael S Sharbaugh, Aman Gupta, Jeff Xu, Miho Fukui, Marc A Simon and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart (British Cardiac Society), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  13. Right ventricular to pulmonary artery coupling in patients with different types of aortic stenosis undergoing TAVI.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Ibrahim SultanDepartment of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Arturo CardounelDepartment of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Islam AbdelkarimHeart and Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Arman KilicDepartment of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Andrew D AlthouseHeart and Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Michael S SharbaughHeart and Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Aman GuptaDivision of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jeff XuDivision of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Miho FukuiHeart and Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Marc A SimonHeart and Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
John T SchindlerHeart and Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Joon S LeeHeart and Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Thomas G GleasonDepartment of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
João L CavalcanteHeart and Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-3632-2074

Funding

Vascular Subphenotypes of Lung DiseaseP01HL103455 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GLADWIN, MARK T · 2011 to 2020
$26.1M
Phase II Trial of Metformin for Pulmonary Hypertension in Heart Failure with Preserved Ejection FractionR01AG058659 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SIMON, MARC A · 2018 to 2022
$3.2M
NHLBI NIH HHS P01 HL103455NIA NIH HHS R01 AG058659
6 · The paper itself

Abstract

objectivesTo evaluate the prognostic value of the ratio between tricuspid annular plane systolic excursion (TAPSE)-pulmonary artery systolic pressure (PASP) as a determinant of right ventricular to pulmonary artery (RV-PA) coupling in patients undergoing transcatheter aortic valve replacement (TAVI).

backgroundRV function and pulmonary hypertension (PH) are both prognostically important in patients receiving TAVI. RV-PA coupling has been shown to be prognostic important in patients with heart failure but not previously evaluated in TAVI patients.

methodsConsecutive patients with severe aortic stenosis who received TAVI from July 2011 through January 2016 and with comprehensive baseline echocardiogram were included. All individual echocardiographic images and Doppler data were independently reviewed and blinded to the clinical information and outcomes. Cox models quantified the effect of TAPSE/PASP quartiles on subsequent all-cause mortality while adjusting for confounders.

resultsA total of 457 patients were included with mean age of 82.8±7.2 years, left ventricular ejection fraction (LVEF) 54%±13%, PASP 44±17 mm Hg. TAPSE/PASP quartiles showed a dose-response relationship with survival. This remained significant (HR for lowest quartile vs highest quartile=2.21, 95% CI 1.07 to 4.57, p=0.03) after adjusting for age, atrial fibrillation, LVEF, stroke volume index, Society of Thoracic Surgeons Predicted Risk of Mortality.

conclusionBaseline TAPSE/PASP ratio is associated with all-cause mortality in TAVI patients as it evaluates RV systolic performance at a given degree of afterload. Incorporation of right-side unit into the risk stratification may improve optimal selection of patients for TAVI.

Indexed as

Transcatheter Aortic Valve ReplacementAgedAged, 80 and overAortic ValveAortic Valve StenosisCardiac Surgical ProceduresEchocardiography, DopplerFemaleFollow-Up StudiesHeart FailureHeart VentriclesHumansMaleMiddle AgedPrognosisPulmonary Arteryaortic stenosissecondary pulmonary hypertensiontranscatheter valve interventions

Identifiers

PMID30093545
PMCPMC6320315

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.