ArticleAJNR. American journal of neuroradiology2018
Quantitative MRI of Perivascular Spaces at 3T for Early Diagnosis of Mild Cognitive Impairment.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Comparison of T1w, T2w, and T1w/T2w MRI methods for perivascular space quantification.Neuroradiology · 2026Article
- Brain glymphatic fluid mapping in Alzheimer's disease: a human MRI and PET study.Brain communications · 2025Article
- Perioperative neurocognitive disorders: a comprehensive review of terminology, clinical implications, and future research directions.Frontiers in neurology · 2025Review
- Article
- Beyond the cerebellum: perivascular space burden in spinocerebellar ataxia type 3 extends to multiple brain regions.Brain communications · 2025Article
- A window into the brain: multimodal MRI assessment of vascular cognitive impairment.Frontiers in neuroscience · 2025Review
- Moderating effect of education on glymphatic function and cognitive performance in mild cognitive impairment.Frontiers in aging neuroscience · 2024Article
- Brain Injury: Response to Injury Wound-Healing Mechanisms and Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes Mellitus.Medicina (Kaunas, Lithuania) · 2023Review
- Effects of Voluntary Physical Exercise on the Neurovascular Unit in a Mouse Model of Alzheimer's Disease.International journal of molecular sciences · 2023Article
- Why Are Perivascular Spaces Important?Medicina (Kaunas, Lithuania) · 2023Review
- The Vascular-Immune Hypothesis of Alzheimer's Disease.Biomedicines · 2023Review
- Automated Methods for Detecting and Quantitation of Enlarged Perivascular spaces on MRI.Journal of magnetic resonance imaging : JMRI · 2023Review
- [An Enlarged Perivascular Space: Clinical Relevance and the Role of Imaging in Aging and Neurologic Disorders].Taehan Yongsang Uihakhoe chi · 2022Review
- Lesion Volume in Relapsing Multiple Sclerosis is Associated with Perivascular Space Enlargement at the Level of the Basal Ganglia.AJNR. American journal of neuroradiology · 2022Article
- A critical guide to the automated quantification of perivascular spaces in magnetic resonance imaging.Frontiers in neuroscience · 2022Review
- Article
- The role of brain perivascular space burden in early-stage Parkinson's disease.NPJ Parkinson's disease · 2021Article
- Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
background and purposeThe limitations inherent in the current methods of diagnosing mild cognitive impairment have constrained the use of early therapeutic interventions to delay the progression of mild cognitive impairment to dementia. This study evaluated whether quantifying enlarged perivascular spaces observed on MR imaging can help differentiate those with mild cognitive impairment from cognitively healthy controls and, thus, have an application in the diagnosis of mild cognitive impairment. MATERIALS AND
methodsWe automated the identification of enlarged perivascular spaces in brain MR Images using a custom quantitative program designed with Matlab. We then quantified the densities of enlarged perivascular spaces for patients with mild cognitive impairment (
resultsQuantified as a percentage of volume fraction (v/v%), densities of enlarged perivascular spaces were calculated to be 2.82 ± 0.40 v/v% for controls and 4.17 ± 0.57 v/v% for the mild cognitive impairment group in the subcortical brain (
conclusionsThe density of enlarged perivascular spaces was found to be significantly higher in those with mild cognitive impairment compared with age-matched healthy control subjects. The density of enlarged perivascular spaces, therefore, may be a useful imaging biomarker for the diagnosis of mild cognitive impairment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.