Evidence map›Paper›PMID 30093406›Full record

ArticleThe Journal of biological chemistry2018

14-3-3γ binds regulator of G protein signaling 14 (RGS14) at distinct sites to inhibit the RGS14:Gα

Kyle J Gerber, Katherine E Squires, John R Hepler

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. RGS14 Regulation of Post-Synaptic Signaling and Spine Plasticity in Brain.International journal of molecular sciences · 2021
    Review
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kyle J GerberFrom the Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322.
Katherine E SquiresFrom the Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322.
John R HeplerFrom the Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322 jhepler@emory.edu.
Emory University · US

Funding

Structure and Function of the G-alpha-i1:RGS14:H-Ras signaling complexR01NS037112 · NINDS · EMORY UNIVERSITY · PI HEPLER, JOHN R · 1998 to 2023
$7.2M
ENNCF - Viral Vector CoreP30NS055077 · NINDS · EMORY UNIVERSITY · PI LEVEY, ALLAN I · 2008 to 2018
$6.8M
Graduate Training in the Pharmacological StudiesT32GM008602 · NIGMS · EMORY UNIVERSITY · PI HALL, RANDY A. · 1996 to 2021
$5.1M
Decoding the RGS14 Interactome/Signalosome in CA2 hippocampal neuronsR21NS087488 · NINDS · EMORY UNIVERSITY · PI HEPLER, JOHN R · 2015 to 2016
$426k
RGS14:14-3-3 Complex Effect on Signaling in Hippocampal CA2 Synaptic PlasticityF31NS098648 · NINDS · EMORY UNIVERSITY · PI GERBER, KYLE JONATHAN · 2016 to 2018
$130k
NIGMS NIH HHS T32 GM008602NINDS NIH HHS F31 NS098648NINDS NIH HHS P30 NS055077NINDS NIH HHS R01 NS037112NINDS NIH HHS R21 NS087488
6 · The paper itself

Abstract

Regulator of G protein signaling 14 (RGS14) is a multifunctional brain scaffolding protein that integrates G protein and Ras/ERK signaling pathways. It is also a nucleocytoplasmic shuttling protein. RGS14 binds active Gα

Indexed as

Signal Transduction14-3-3 ProteinsAluminum CompoundsAnimalsBinding SitesCell NucleusEnergy TransferFluoridesHEK293 CellsHippocampusHumansLearningLong-Term PotentiationMemoryNeuronsPhosphorylation14-3-3 ProteinsAluminum CompoundsFluoridesRgs14 protein, ratRGS Proteinstetrafluoroaluminate14–3-3 proteinGoLoco motifG proteinG protein regulatory (GPR) motifGαiheterotrimeric G proteinH-Rasnucleusprotein-protein interactionRas proteinregulator of G protein signaling (RGS)RGS14

Identifiers

PMID30093406
PMCPMC6153293
OpenAlexW2885855737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.