Evidence map›Paper›PMID 30093403›Full record

ArticleThe Journal of biological chemistry2018

AIF promotes a JNK1-mediated cadherin switch independently of respiratory chain stabilization.

Andrew J Scott, Sierra A Walker, Joshua J Krank, Amanda S Wilkinson, Kaitlyn M Johnson, Eric M Lewis, John C Wilkinson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andrew J ScottFrom the Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108 and.
Sierra A WalkerFrom the Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108 and.
Joshua J KrankFrom the Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108 and.
Amanda S WilkinsonFrom the Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108 and.
Kaitlyn M JohnsonFrom the Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108 and.
Eric M Lewisthe Department of Chemistry, Mathematics and Physics, Clarion University of Pennsylvania, Clarion, Pennsylvania 16214.
John C WilkinsonFrom the Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108 and john.wilkinson@ndsu.edu.ORCID 0000-0002-2540-1850
North Dakota State University · USUniversity of Pennsylvania · US

Funding

Targeting CLEC-2/podoplanin as a therapeutic strategy for pancreatic cancerP20GM109024 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI Sanku Mallik · 2016 to 2026
$20.5M
AIF-mediated Control of Mitochondrial Biogenesis, Metabolism, and Cellular Redox BalanceR15CA206067 · NCI · NORTH DAKOTA STATE UNIVERSITY · PI WILKINSON, JOHN CURLEE · 2016 to 2016
$435k
NCI NIH HHS R15 CA206067NIGMS NIH HHS P20 GM109024
6 · The paper itself

Abstract

Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein occasionally involved in cell death that primarily regulates mitochondrial energy metabolism under normal cellular conditions. AIF catalyzes the oxidation of NADH

Indexed as

Electron TransportAntigens, CDApoptosisApoptosis Inducing FactorCadherinsCatalysisCell LineEnergy MetabolismEnzyme ActivationExtracellular Signal-Regulated MAP KinasesHumansMitochondriaMitogen-Activated Protein Kinase 8OxidantsOxidation-ReductionOxidative StressAIFM1 protein, humanAntigens, CDApoptosis Inducing FactorCadherinsCDH1 protein, humanExtracellular Signal-Regulated MAP KinasesMitogen-Activated Protein Kinase 8Oxidantsp38 Mitogen-Activated Protein Kinasescancercell signalingepithelial-mesenchymal transition (EMT)MAPKmetabolismmitochondriaoxidative stress

Identifiers

PMID30093403
PMCPMC6153284
OpenAlexW2886751939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.