Evidence map›Paper›PMID 30093399›Full record

ArticleHaematologica2019

A novel deep targeted sequencing method for minimal residual disease monitoring in acute myeloid leukemia.

Esther Onecha, Maria Linares, Inmaculada Rapado, Yanira Ruiz-Heredia, Pilar Martinez-Sanchez, Teresa Cedena, Marta Pratcorona, Jaime Perez Oteyza, Pilar Herrera, Eva Barragan and 12 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 13 institutions in 3 countries.

Esther OnechaHematology Department, Hospital Universitario 12 de Octubre, Madrid.
Maria LinaresHematology Department, Hospital Universitario 12 de Octubre, Madrid.
Inmaculada RapadoHematology Department, Hospital Universitario 12 de Octubre, Madrid.
Yanira Ruiz-HerediaHematology Department, Hospital Universitario 12 de Octubre, Madrid.
Pilar Martinez-SanchezHematology Department, Hospital Universitario 12 de Octubre, Madrid.
Teresa CedenaHematology Department, Hospital Universitario 12 de Octubre, Madrid.
Marta PratcoronaHematology Department, Hospital Santa Creu i Sant Pau, Barcelona.
Jaime Perez OteyzaHematology Department, Hospital Universitario Sanchinarro, Madrid.
Pilar HerreraHematology Department, Hospital Universitario Ramon y Cajal, Madrid.
Eva BarraganComplutense University, Madrid.
Pau MontesinosComplutense University, Madrid.
Jose Antonio Garcia VelaDepartment of Hematology, Hospital Universitario de Getafe, Madrid.
Elena MagroHematology Department, Hospital Universitario Principe de Asturias, Madrid.
Eduardo AnguitaHematology Department, Hospital Clínico San Carlos, IdISSC, UCM, Madrid.
Angela FigueraHematology Department, Hospital Universitario de la Princesa, Madrid.
Rosalia RiazaHematology Department, Hospital Universitario Severo Ochoa, Madrid.
Pilar Martinez-BarrancoHematology Department, Hospital Universitario Fundación Alcorcón, Madrid, Spain.
Beatriz Sanchez-VegaHematology Department, Hospital Universitario 12 de Octubre, Madrid.
Josep NomdedeuHematology Department, Hospital Santa Creu i Sant Pau, Barcelona.
Miguel GallardoHematological Malignancies Clinical Research Unit, CNIO, Madrid.
Joaquin Martinez-LopezHematology Department, Hospital Universitario 12 de Octubre, Madrid.
Rosa AyalaHematology Department, Hospital Universitario 12 de Octubre, Madrid rosam.ayala@salud.madrid.org.
Hospital Universitario 12 De Octubre · ESMolecular Oncology (United States) · USCentro de Investigación Biomédica en Red de Cáncer · ESCentro Hospitalar de Lisboa Ocidental · PTUniversidad Complutense de Madrid · ESHospital Universitario de Getafe · ESHospital Universitario de La Princesa · ESHospital Universitario Fundación Alcorcón · ESHospital Universitario HM Sanchinarro · ESHospital Universitario Príncipe de Asturias · ESHospital Universitario Ramón y Cajal · ESHospital Universitario Severo Ochoa · ESInstituto de Investigación Sanitaria del Hospital Clínico San Carlos · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A high proportion of patients with acute myeloid leukemia who achieve minimal residual disease negative status ultimately relapse because a fraction of pathological clones remains undetected by standard methods. We designed and validated a high-throughput sequencing method for minimal residual disease assessment of cell clonotypes with mutations of

Indexed as

Biomarkers, TumorHigh-Throughput Nucleotide SequencingAdultFemaleHumansKaplan-Meier EstimateLeukemia, Myeloid, AcuteMaleMiddle AgedNeoplasm, ResidualNucleophosminPolymorphism, Single NucleotidePrognosisProportional Hazards ModelsWorkflowBiomarkers, TumorNPM1 protein, humanNucleophosmin

Identifiers

PMID30093399
PMCPMC6355493
OpenAlexW2885961002

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.