Evidence map›Paper›PMID 30093396›Full record

ArticleHaematologica2018

ASXL2 regulates hematopoiesis in mice and its deficiency promotes myeloid expansion.

Vikas Madan, Lin Han, Norimichi Hattori, Weoi Woon Teoh, Anand Mayakonda, Qiao-Yang Sun, Ling-Wen Ding, Hazimah Binte Mohd Nordin, Su Lin Lim, Pavithra Shyamsunder and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Observational
  7. The mechanisms of pathological extramedullary hematopoiesis in diseases.Cellular and molecular life sciences : CMLS · 2020
    Review
  8. Article
  9. Review
  10. The role of ASXL1 in hematopoiesis and myeloid malignancies.Cellular and molecular life sciences : CMLS · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 10 institutions in 5 countries.

Vikas MadanCancer Science Institute of Singapore, National University of Singapore csivm@nus.edu.sg nhattor@med.showa-u.ac.jp sly7012@cgmh.org.tw.
Lin HanCancer Science Institute of Singapore, National University of Singapore.
Norimichi HattoriCancer Science Institute of Singapore, National University of Singapore csivm@nus.edu.sg nhattor@med.showa-u.ac.jp sly7012@cgmh.org.tw.
Weoi Woon TeohCancer Science Institute of Singapore, National University of Singapore.
Anand MayakondaCancer Science Institute of Singapore, National University of Singapore.
Qiao-Yang SunCancer Science Institute of Singapore, National University of Singapore.
Ling-Wen DingCancer Science Institute of Singapore, National University of Singapore.
Hazimah Binte Mohd NordinCancer Science Institute of Singapore, National University of Singapore.
Su Lin LimCancer Science Institute of Singapore, National University of Singapore.
Pavithra ShyamsunderCancer Science Institute of Singapore, National University of Singapore.
Pushkar DakleCancer Science Institute of Singapore, National University of Singapore.
Janani SundaresanCancer Science Institute of Singapore, National University of Singapore.
Ngan B DoanDepartment of Pathology and Laboratory Medicine, Santa Monica-University of California-Los Angeles Medical Center, Los Angeles, CA, USA.
Masashi SanadaDepartment of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Japan.
Aiko Sato-OtsuboDepartment of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Japan.
Manja MeggendorferMLL Munich Leukemia Laboratory, Germany.
Henry YangCancer Science Institute of Singapore, National University of Singapore.
Jonathan W SaidDepartment of Pathology and Laboratory Medicine, Santa Monica-University of California-Los Angeles Medical Center, Los Angeles, CA, USA.
Seishi OgawaDepartment of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Japan.
Torsten HaferlachMLL Munich Leukemia Laboratory, Germany.
Der-Cherng LiangDivision of Pediatric Hematology-Oncology, Mackay Memorial Hospital and Mackay Medical College, Taipei, Taiwan.
Lee-Yung ShihDivision of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan csivm@nus.edu.sg nhattor@med.showa-u.ac.jp sly7012@cgmh.org.tw.
Tsuyoshi NakamakiDivision of Hematology, Department of Medicine, School of Medicine, Showa University, Shinagawa-Ku, Tokyo, Japan.
Q Tian WangDepartment of Biological Sciences, University of Illinois at Chicago, IL, USA.
H Phillip KoefflerCancer Science Institute of Singapore, National University of Singapore.
National University Cancer Institute, Singapore · SGNational University of Singapore · SGKyoto University · JPMunich Leukemia Laboratory (Germany) · DEChang Gung University · TWLos Angeles Medical Center · USMackay Medical College · TWShowa University · JPUniversity of California, Los Angeles · USUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromosomal translocation t(8;21)(q22;q22) which leads to the generation of oncogenic RUNX1-RUNX1T1 (AML1-ETO) fusion is observed in approximately 10% of acute myelogenous leukemia (AML). To identify somatic mutations that co-operate with t(8;21)-driven leukemia, we performed whole and targeted exome sequencing of an Asian cohort at diagnosis and relapse. We identified high frequency of truncating alterations in

Indexed as

Acute DiseaseAnimalsCell DifferentiationCell ProliferationGene Expression ProfilingHematopoiesisHumansLeukemia, MyeloidMice, 129 StrainMice, Inbred C57BLMice, KnockoutMyeloid CellsMyelopoiesisRepressor ProteinsASXL2 protein, mouseRepressor Proteins

Identifiers

PMID30093396
PMCPMC6269306
OpenAlexW2887994251

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.