Evidence map›Paper›PMID 30093392›Full record

ArticleJournal of clinical microbiology2018

Rapid Direct Susceptibility Testing from Positive Blood Cultures by the Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry-Based Direct-on-Target Microdroplet Growth Assay.

Evgeny A Idelevich, Luise M Storck, Katrin Sparbier, Oliver Drews, Markus Kostrzewa, Karsten Becker

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
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  4. From Species to Genes: A New Diagnostic Paradigm.Antibiotics (Basel, Switzerland) · 2024
    Review
  5. Article
  6. Article
  7. Review
  8. Rapid detection of antimicrobial resistance in methicillin-resistantFrontiers in cellular and infection microbiology · 2023
    Article
  9. Article
  10. "Omic" Approaches to Bacteria and Antibiotic Resistance Identification.International journal of molecular sciences · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Detection of Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2021
    Review
  19. Performance of a MALDI-TOF mass spectrometry-based method for rapid detection of third-generation oxymino-cephalosporin-resistant Escherichia coli and Klebsiella spp. from blood cultures.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Evgeny A IdelevichInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany evgeny.idelevich@ukmuenster.de.
Luise M StorckInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Katrin SparbierBruker Daltonik GmbH, Bremen, Germany.
Oliver DrewsBruker Daltonik GmbH, Bremen, Germany.
Markus KostrzewaBruker Daltonik GmbH, Bremen, Germany.
Karsten BeckerInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany.ORCID 0000-0002-6391-1341
Bruker (Germany) · DEUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recently developed direct-on-target microdroplet growth assay (DOT-MGA) allows rapid universal antimicrobial susceptibility testing (AST) using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). Here, we investigated a direct application of this method on positive blood cultures (BCs) for the acceleration of sepsis diagnostics. Blood samples spiked with meropenem-nonsusceptible and meropenem-susceptible

Indexed as

Blood CultureSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAnti-Bacterial AgentsBacteriaBacterial Typing TechniquesCulture MediaDrug Resistance, BacterialHumansMicrobial Sensitivity TestsSensitivity and SpecificitySepsisTime FactorsAnti-Bacterial AgentsCulture MediaASTblood culturecarbapenem resistancedirect-on-target microdroplet growth assayMALDI-TOFrapid susceptibility testing

Identifiers

PMID30093392
PMCPMC6156312
OpenAlexW2885698740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.