Evidence map›Paper›PMID 30093361›Full record

SynthesisSleep medicine reviews2018

A lack of consistent brain alterations in insomnia disorder: An activation likelihood estimation meta-analysis.

Masoud Tahmasian, Khadijeh Noori, Fateme Samea, Mojtaba Zarei, Kai Spiegelhalder, Simon B Eickhoff, Eus Van Someren, Habibolah Khazaie, Claudia R Eickhoff

Abstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Sleep medicine reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Distinct functional brain abnormalities in insomnia disorder and obstructive sleep apnea.European archives of psychiatry and clinical neuroscience · 2023
    Pooled it
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  12. Trial
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  14. Article
  15. Neuroimaging findings in sleep disorders: A review article.Neurobiology of sleep and circadian rhythms · 2026
    Review
  16. Article
  17. Mechanisms Linking Insomnia and Cardiometabolic Disease Risk.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  18. Article
  19. Review
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Masoud TahmasianInstitute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran.
Khadijeh NooriSleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Fateme SameaInstitute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran.
Mojtaba ZareiInstitute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran.
Kai SpiegelhalderDepartment of Psychiatry and Psychotherapy, Medical Centre - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Simon B EickhoffInstitute of Systems Neuroscience, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany; Institute of Neuroscience and Medicine (INM-1; INM-7), Research Center Jülich, Jülich, Germany.
Eus Van SomerenDepartment of Sleep and Cognition, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 Amsterdam BA, The Netherlands; Department of Psychiatry and Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Neuroscience Campus Amsterdam, VU University and Medical Center, De Boelelaan 1187, 1081 Amsterdam HV, The Netherlands.
Habibolah KhazaieSleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: hakhazaie@gmail.com.
Claudia R EickhoffInstitute of Neuroscience and Medicine (INM-1; INM-7), Research Center Jülich, Jülich, Germany; Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Funding

Meta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5M
NIMH NIH HHS R01 MH074457
6 · The paper itself

Abstract

Insomnia disorder is a prevalent sleep disorder, which affects about 10% of general population. However, its neural mechanisms are poorly understood. Recently, several structural and functional neuroimaging studies have been conducted in patients with insomnia disorder, but these studies have yielded diverse findings. Here, we aimed to identify consistent patterns of abnormal brain alterations in insomnia disorder by performing a quantitative coordinate-based meta-analysis. Following the preferred reporting for systematic reviews and meta-analyses statement, we searched PubMed database and used reference tracking and finally retrieved 19 eligible studies (six task-based functional magnetic resonance imaging, eight resting-state functional magnetic resonance imaging, three voxel-based morphometry, and two positron emission tomography). We extracted peak coordinates from these studies and tested for convergence using the activation likelihood estimation method. Using this method, we found no significant convergent evidence for combination of structural atrophy and functional disturbances across previous studies (p = 0.914). Inconsistencies across these studies might be related to heterogonous clinical populations, the explorative nature of these studies in combination with small sample sizes, different experimental designs, and various preprocessing and statistical approaches. Future neuroimaging studies on insomnia disorder should include larger well-characterized samples, as well as standard imaging and analysis protocols.

Indexed as

BrainHumansMagnetic Resonance ImagingPositron-Emission TomographySleep Initiation and Maintenance DisordersALE meta-analysisfMRIInsomnia disorderPETVBM

Identifiers

PMID30093361
PMCPMC7965842

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.