ArticleMolecular metabolism2018
Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle.
Article in Molecular metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Glycogen supercompensation in skeletal muscle after cycling or running followed by a high carbohydrate intake the following days: a systematic review and meta-analysis.Frontiers in physiology · 2025Pooled it
- Morning priming exercises for explosive performance: time course effects of two-way ballistic and strength-based protocols.Biology of sport · 2026Article
- Periodizing Exercise Medicine Prescription for Patients with Cancer: A Narrative Opinion.Sports medicine (Auckland, N.Z.) · 2025Review
- The Effects of a High Carbohydrate Diet Combined with High Molecular Weight Carbohydrate Supplementation on Anaerobic Performance and Oxidative Stress in Elite Swimmers.Journal of clinical medicine · 2025Article
- Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men.Nature metabolism · 2025Article
- Soft, Modular Power for Composing Robots with Embodied Energy.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Visual supercompensation following short-term exhaustive exercise.Frontiers in physiology · 2025Article
- Genetic reduction of skeletal muscle glycogen synthase 1 abundance reveals that the refeeding-induced reversal of elevated insulin-stimulated glucose uptake after exercise is not attributable to achieving a high muscle glycogen concentration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Four-week experimental plus 1-week taper period using live high train low does not alter muscle glycogen content.European journal of applied physiology · 2024Article
- Regulation of peripheral tissue substrate metabolism by the gut-derived hormone ghrelin.Metabolism open · 2024Review
- Exercise training adaptations in liver glycogen and glycerolipids require hepatic AMP-activated protein kinase in mice.American journal of physiology. Endocrinology and metabolism · 2024Article
- Effect of an acute long-duration exercise bout on skeletal muscle lipid droplet morphology, GLUT 4 protein, and perilipin protein expression.European journal of applied physiology · 2023Article
- AMPKγ3 Controls Muscle Glucose Uptake in Recovery From Exercise to Recapture Energy Stores.Diabetes · 2023Article
- Novel Expression ofMetabolites · 2023Article
- An Acute Bout of Endurance Exercise Does Not Prevent the Inhibitory Effect of Caffeine on Glucose Tolerance the following Morning.Nutrients · 2023Article
- The role of glycogen phosphorylase in glycogen biogenesis in skeletal muscle after exercise.Sports medicine and health science · 2023Review
- Insights into the development of insulin resistance: Unraveling the interaction of physical inactivity, lipid metabolism and mitochondrial biology.Frontiers in physiology · 2023Review
- An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination.Cancer research · 2022Article
- A century of exercise physiology: key concepts in regulation of glycogen metabolism in skeletal muscle.European journal of applied physiology · 2022Review
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Corrections and comments
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Authors and funding
17 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA single bout of exercise followed by intake of carbohydrates leads to glycogen supercompensation in prior exercised muscle. Our objective was to illuminate molecular mechanisms underlying this phenomenon in skeletal muscle of man.
methodsWe studied the temporal regulation of glycogen supercompensation in human skeletal muscle during a 5 day recovery period following a single bout of exercise. Nine healthy men depleted (day 1), normalized (day 2) and supercompensated (day 5) muscle glycogen in one leg while the contralateral leg served as a resting control. Euglycemic hyperinsulinemic clamps in combination with leg balance technique allowed for investigating insulin-stimulated leg glucose uptake under these 3 experimental conditions. Cellular signaling in muscle biopsies was investigated by global proteomic analyses and immunoblotting. We strengthened the validity of proposed molecular effectors by follow-up studies in muscle of transgenic mice.
resultsSustained activation of glycogen synthase (GS) and AMPK in combination with elevated expression of proteins determining glucose uptake capacity were evident in the prior exercised muscle. We hypothesize that these alterations offset the otherwise tight feedback inhibition of glycogen synthesis and glucose uptake by glycogen. In line with key roles of AMPK and GS seen in the human experiments we observed abrogated ability for glycogen supercompensation in muscle with inducible AMPK deletion and in muscle carrying a G6P-insensitive form of GS in muscle.
conclusionOur study demonstrates that both AMPK and GS are key regulators of glycogen supercompensation following a single bout of glycogen-depleting exercise in skeletal muscle of both man and mouse.
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