Evidence map›Paper›PMID 30093310›Full record

ArticleSurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery2018

A comparison of rodent models of vertical sleeve gastrectomy.

Rafael Alvarez, Alfor G Lewis, Mouhamadoul H Toure, Randy J Seeley

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. A rodent model of partial intestinal diversion: a novel metabolic operation.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2020
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rafael AlvarezDepartment of Surgery, University of Michigan, Ann Arbor, Michigan. Electronic address: rafalv@med.umich.edu.
Alfor G LewisDepartment of Surgery, University of Michigan, Ann Arbor, Michigan.
Mouhamadoul H ToureDepartment of Surgery, University of Michigan, Ann Arbor, Michigan.
Randy J SeeleyDepartment of Surgery, University of Michigan, Ann Arbor, Michigan.
University of Michigan · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joyce Lee · 2010 to 2026
$20.3M
Obesity Surgery Scientist Training ProgramT32DK108740 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin Brigham Dimick, RANDY J SEELEY · 2016 to 2026
$2.2M
NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS T32 DK108740
6 · The paper itself

Abstract

backgroundAlthough vertical sleeve gastrectomy (VSG) is fashioned in humans by applying multiple staple loads, rodent VSG is generally created through a single-staple load application.

objectivesTo investigate the impact of a 2-staple load VSG rat model more closely resembling the multistaple load operation done in humans on weight, metabolic outcomes, and the microbiome and how these compare with those obtained with the standard one-staple load model.

settingUniversity research facility, United States.

methodsHigh-fat diet-induced obese male rats were randomized to single-staple load VSG (VSG1), 2-staple load VSG (VSG2), or sham operation (Sham). Outcomes included weight and composition, food intake, glucose metabolism, lipids, bile acids, and intestinal microbiome. Statistical comparisons were performed using analysis of variance.

resultsBoth procedures resulted in substantial weight and body fat loss compared with Sham-treated animals. Weight loss was modestly greater for VSG2 compared with VSG1. Food intake was reduced in both procedures and accounted for the observed weight reduction. Glucose tolerance and plasma and hepatic lipid profiles were improved comparably in VSG1 and VSG2 relative to Sham. Bile acids were higher for VSG2 compared with Sham but not significantly different between VSG1 and VSG2. Neither procedure impacted intestinal microbiome richness and diversity compared with Sham across multiple intestinal sections. Colonic Actinobacteria was more abundant in VSG2 than in Sham. Relative abundances of bacterial phyla did not differ among VSG1, VSG2, and Sham across the remaining intestinal sections.

conclusionsAlthough VSG1 or VSG2 offer effective and overall comparable platforms for the study of obesity, VSG2 resulted in superior weight loss.

Indexed as

Analysis of VarianceAnimalsBariatric SurgeryBlood GlucoseDiet, High-FatDisease Models, AnimalGastrectomyGastrointestinal MicrobiomeLipid MetabolismMaleObesityOrgan SizeRandom AllocationRats, Long-EvansWeight LossBlood GlucoseAnimal experimentBariatric surgeryGlucose metabolismIntestinal microbiomeLipid metabolismMetabolic surgeryObesity surgerySleeve gastrectomySurgical techniqueVertical sleeve gastrectomyWeight loss surgery

Identifiers

PMID30093310
PMCPMC6242744
OpenAlexW2810037044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.