Evidence map›Paper›PMID 30093115›Full record

ArticleBiochemical and biophysical research communications2018

Intraperitoneal injection of MSC-derived exosomes prevent experimental bronchopulmonary dysplasia.

Rudolf K Braun, Chandramu Chetty, Vivek Balasubramaniam, Ryan Centanni, Kristin Haraldsdottir, Peiman Hematti, Marlowe W Eldridge

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.

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  4. Extracellular vesicle-mediated mechanisms and therapeutic potential in acute lung injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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  9. [Expression and regulatory mechanism of miR-34a in neonatal rat model of bron-chopulmonary dysplasia induced by hyperoxia].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rudolf K BraunDepartment of Pediatrics, University of Wisconsin Madison, Madison, WI, USA. Electronic address: rudolf.braun@wisc.edu.
Chandramu ChettyDepartment of Pediatrics, University of Wisconsin Madison, Madison, WI, USA.
Vivek BalasubramaniamDepartment of Pediatrics, University of Wisconsin Madison, Madison, WI, USA.
Ryan CentanniDepartment of Pediatrics, University of Wisconsin Madison, Madison, WI, USA.
Kristin HaraldsdottirDepartment of Pediatrics, University of Wisconsin Madison, Madison, WI, USA.
Peiman HemattiDepartment of Medicine, University of Wisconsin Madison, Madison, WI, USA; Carbone Cancer Center, University of Wisconsin Madison, Madison, WI, USA.
Marlowe W EldridgeDepartment of Pediatrics, University of Wisconsin Madison, Madison, WI, USA. Electronic address: meldridge@pediatrics.wisc.edu.
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Training Program in Translational Cardiovascular Science (TPTCS)T32HL007936 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Gail A Robertson · 2001 to 2026
$11.6M
Right Heart-Pulmonary Vascular Interactions in Bronchopulmonary DysplasiaR01HL115061 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI ELDRIDGE, MARLOWE · 2012 to 2016
$3.2M
Special BD LSR FortessaS10OD018202 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI PATANKAR, MANISH S · 2014 to 2014
$351k
NCI NIH HHS P30 CA014520NHLBI NIH HHS R01 HL115061NHLBI NIH HHS T32 HL007936NIH HHS S10 OD018202
6 · The paper itself

Abstract

Mesenchymal stromal cell (MSC) derived exosomes mediate tissue protection and regeneration in many injuries and diseases by modulating cell protein production, protecting from apoptosis, inhibiting inflammation, and increasing angiogenesis. In the present study, daily intraperitoneal injection of MSC-derived exosomes protected alveolarization and angiogenesis in a newborn rat model of bronchopulmonary dysplasia (BPD) induced by 14 days of neonatal hyperoxia exposure (85% O

Indexed as

AnimalsAnimals, NewbornBone Marrow CellsBronchopulmonary DysplasiaCardiomegalyDisease Models, AnimalExosomesFemaleGene Expression RegulationHyperoxiaInjections, IntraperitonealLungMesenchymal Stem CellsNeovascularization, PhysiologicOxygenPregnancyOxygenVascular Endothelial Growth Factor Avascular endothelial growth factor A, ratBronchopulmonary dysplasiaChronic lung diseaseExosomesLung prematurityMesenchymal stromal cells

Identifiers

PMID30093115
PMCPMC6398932
OpenAlexW2885557301

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.