SynthesisBiological psychiatry. Cognitive neuroscience and neuroimaging2018
Atypicality of the N170 Event-Related Potential in Autism Spectrum Disorder: A Meta-analysis.
Synthesis in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 6 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- Neurophysiological alterations during sensory processing in autism - a meta-analysis.European child & adolescent psychiatry · 2026Pooled it
- Coactivation of Autonomic and Central Nervous Systems During Processing of Socially Relevant Information in Autism Spectrum Disorder: A Systematic Review.Neuropsychology review · 2024Pooled it
- Resting-state EEG power differences in autism spectrum disorder: a systematic review and meta-analysis.Translational psychiatry · 2023Pooled it
- Brain correlates of declarative memory atypicalities in autism: a systematic review of functional neuroimaging findings.Molecular autism · 2023Pooled it
- A systematic review of observational, naturalistic, and neurophysiological outcome measures of nonpharmacological interventions for autism.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2022Pooled it
- Cortical Auditory Processing of Simple Stimuli Is Altered in Autism: A Meta-analysis of Auditory Evoked Responses.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Pooled it
- Empathy and event related potentials before and after EEG based neurofeedback training in autistic adolescents.Scientific reports · 2025Trial
- A single-blind active-control randomized controlled trial of group-based social competence intervention.Scientific reports · 2025Trial
- Distinct Temporal Stages of Infant Brain Processing Associate With Early Versus Later Autism Diagnosis.Developmental science · 2026Article
- Social Functioning in Autistic Children with Below-Average vs. Average IQ: Limited Behavioral and Neural Evidence of Group Differences.Journal of autism and developmental disorders · 2026Article
- Uncovering putative neural mechanisms of neurotherapeutic impacts on EEG using the Human Neocortical Neurosolver.bioRxiv : the preprint server for biology · 2026Article
- Using EEG and Eye Tracking to Evaluate an Emotion Recognition iPad App for Autistic Children.Clinical EEG and neuroscience · 2026Article
- Reduced social prioritization: An underlying mechanism driving slower latency to look at faces in autism.Journal of psychopathology and clinical science · 2026Article
- Investigating associations between maternal neural responsivity and infant developmental outcomes.Developmental psychology · 2026Article
- Characterizing the Relationship Among the Social Competence Elements in Autistic Adolescents.Autism research : official journal of the International Society for Autism Research · 2025Article
- The association between infant EEG aperiodic exponent and the trajectory of restricted and repetitive behaviors for toddlers with and without autism.Journal of neurodevelopmental disorders · 2025Article
- Face perception, attention, and memory as predictors of social change in autistic children.Journal of neurodevelopmental disorders · 2025Observational
- Specific dynamic facial expression evoked responses show distinct perceptual and attentional features in autism connected to social communication and GABA phenotypes.Scientific reports · 2025Article
- Social orienting in prematurely born preschoolers: a case control study showing altered neural tuning towards voices, not faces.Molecular autism · 2025Article
- Automatic and affective processing of faces as mechanisms of passing as non-autistic in adolescence.Scientific reports · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAutism spectrum disorder (ASD) is associated with impaired face processing. The N170 event-related potential (ERP) has been considered a promising neural marker of this impairment. However, no quantitative review to date has integrated the literature to assess whether the N170 response to faces in individuals with ASD differs from that of typically developing (TD) individuals.
methodsThis meta-analysis examined the corpus of literature investigating difference in N170 response to faces in individuals with ASD and without ASD. Data from 23 studies (N
resultsOn average, N170 latencies to faces were delayed in individuals with ASD, but amplitudes did not differ for individuals with ASD and TD individuals. Moderator analyses revealed that N170 amplitudes were smaller in magnitude in the ASD participants relative to the TD participants in adult samples and in those with higher cognitive ability. However, effects differed as a function of hemisphere of recording. No evidence of publication bias was found.
conclusionsAtypicality of N170-particularly latency-to faces appears to be a specific biomarker of social-communicative dysfunction in ASD and may relate to differential developmental experiences and use of compensatory cognitive mechanisms. Future research should examine phenotypic differences that contribute to N170 heterogeneity, as well as specificity of N170 differences in ASD versus non-ASD clinical populations, and N170 malleability with treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.