ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2018
Evaluation of Analgesic Efficacy of Meloxicam and 2 Formulations of Buprenorphine after Laparotomy in Female Sprague-Dawley Rats.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Grimace scale, burrowing, and nest building for the assessment of post-surgical pain in mice and rats-A systematic review.Frontiers in veterinary science · 2022Pooled it
- Pharmacokinetics and preliminary data on safety of meloxicam subcutaneous extended-release formulation in Sprague-Dawley rats.Frontiers in veterinary science · 2026Article
- Behavioral Assessment of Tramadol and Meloxicam Effects on Postoperative Pain in a Rat Craniotomy Model.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- A comparative evaluation of the efficacy of three commonly used diode lasers (810, 940, and 980-nanometer) to solder skin incisions: an experimental study in the rat.Lasers in medical science · 2025Article
- Pharmacokinetics of Injectable Meloxicam and Buprenorphine in the Naked Mole-Rat (Journal of the American Association for Laboratory Animal Science : JAALAS · 2024Article
- Refinement of the motorised laminectomy-assisted rat spinal cord injury model by analgesic treatment.PloS one · 2024Article
- Development of opioid analgesic tolerance in rat to extended-release buprenorphine formulated for laboratory subjects.PloS one · 2024Article
- Evaluation and comparison of pharmacokinetic profiles and safety of two extended-release buprenorphine formulations in common marmosets (Callithrix jacchus).Scientific reports · 2023Article
- A Review of Long-acting Parenteral Analgesics for Mice and Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Review
- Pharmacokinetics and Efficacy of a Long-lasting, Highly Concentrated Buprenorphine Solution in Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- Pharmacokinetic and Histopathologic Study of an Extended-Release, Injectable Formulation of Buprenorphine in Sprague-Dawley Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- Indicators of Postoperative Pain in Syrian Hamsters (Comparative medicine · 2021Article
- Injection-site Reactions to Sustained-release Meloxicam in Sprague-Dawley Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Design and in vivo evaluation of a microparticulate depot formulation of buprenorphine for veterinary use.Scientific reports · 2020Article
- Female Urine-induced Ultrasonic Vocalizations in Male C57BL/6J Mice as a Proxy Indicator for Postoperative Pain.Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Clinical Management of Pain in Rodents.Comparative medicine · 2019Review
- A Review of Pain Assessment Methods in Laboratory Rodents.Comparative medicine · 2019Review
- Concentration-dependent Toxicity after Subcutaneous Administration of Meloxicam to C57BL/6N Mice (Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Managing postoperative pain in rodents is an important part of any animal care and use program, and identifying an optimal analgesic plan for a surgical procedure is critical to providing for animal welfare. Opioids and NSAID are commonly used in rodents, but few studies have evaluated their efficacy in surgical models. The current study aimed to evaluate the therapeutic efficacy of clinically relevant doses of buprenorphine (2 formulations) or meloxicam used in combination with ketamine and xylazine anesthesia in a Sprague-Dawley rat ovariohysterectomy surgical model. Rats received either subcutaneous saline once daily for 3 d, low-dose (0.05 mg/kg SC) or high-dose (0.1 mg/kg SC) buprenorphine twice daily for 3 d, a single injection of sustained-release buprenorphine (1.2 mg/kg SC), or low-dose (1 mg/kg SC) or high-dose (2 mg/kg SC) meloxicam once daily for 3 d. Clinical analgesic efficacy was assessed over 8 d according to cageside observation scoring, body weight, and behavioral testing. Ovariohysterectomy was associated with 2 d of postoperative pain, and all 3 buprenorphine dosing strategies and both doses of meloxicam demonstrated varying amounts of analgesia. Given the results of the current study, we recommend 0.05 mg/kg SC buprenorphine at least twice daily or a single dose of 1.2 mg/kg SC of sustained-release buprenorphine for rats undergoing midline laparotomy with ovariohysterectomy. Alternatively, meloxicam at 1 to 2 mg/kg SC once daily could be used for this indication.
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Registered trials
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