Evidence map›Paper›PMID 30092829›Full record

Observational studyBreast cancer research : BCR2018

Long-term exposure to insulin and volumetric mammographic density: observational and genetic associations in the Karma study.

Signe Borgquist, Ann H Rosendahl, Kamila Czene, Nirmala Bhoo-Pathy, Mozhgan Dorkhan, Per Hall, Judith S Brand

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Breast cancer research : BCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Genetic architecture of mammographic density as a risk factor for breast cancer: a systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Signe BorgquistDivision of Oncology and Pathology, Clinical Sciences, Lund University, SE-221 85, Lund, Sweden. signe.borgquist@med.lu.se.ORCID 0000-0001-7938-8893
Ann H RosendahlDivision of Oncology and Pathology, Clinical Sciences, Lund University, SE-221 85, Lund, Sweden.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Solna, Sweden.
Nirmala Bhoo-PathyJulius Centre University of Malaya (JCUM), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Mozhgan DorkhanGlobal Medical Affairs, Novo Nordisk A/S, Søborg, Denmark.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Solna, Sweden.
Judith S BrandDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Solna, Sweden.
Lund University · SEKarolinska Institutet · SEÖrebro University · SEUniversity of Malaya · MY

Funding

Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Cancer Research UK C1287/A10118Cancer Research UK C1287/A10710Cancer Research UK C1287/A16563CIHRNCI NIH HHS U19 CA148065
6 · The paper itself

Abstract

backgroundLong-term insulin exposure has been implicated in breast cancer etiology, but epidemiological evidence remains inconclusive. The aims of this study were to investigate the association of insulin therapy with mammographic density (MD) as an intermediate phenotype for breast cancer and to assess associations with long-term elevated circulating insulin levels using a genetic score comprising 18 insulin-associated variants.

methodsWe used data from the KARolinska MAmmography (Karma) project, a Swedish mammography screening cohort. Insulin-treated patients with type 1 (T1D, n = 122) and type 2 (T2D, n = 237) diabetes were identified through linkage with the Prescribed Drug Register and age-matched to 1771 women without diabetes. We assessed associations with treatment duration and insulin glargine use, and we further examined MD differences using non-insulin-treated T2D patients as an active comparator. MD was measured using a fully automated volumetric method, and analyses were adjusted for multiple potential confounders. Associations with the insulin genetic score were assessed in 9437 study participants without diabetes.

resultsCompared with age-matched women without diabetes, insulin-treated T1D patients had greater percent dense (8.7% vs. 11.4%) and absolute dense volumes (59.7 vs. 64.7 cm

conclusionsThe consistency in direction of association for insulin treatment and the insulin genetic score with the absolute dense volume suggest a causal influence of long-term increased insulin exposure on mammographic dense breast tissue.

Indexed as

AdultAgedBreastBreast DensityBreast NeoplasmsCase-Control StudiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansHypoglycemic AgentsInsulinInsulin GlargineMammographyHypoglycemic AgentsInsulinInsulin GlargineBreast cancerDiabetesInsulinInsulin genetic scoreMammographic density

Identifiers

PMID30092829
PMCPMC6085687
OpenAlexW2885360465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.