ArticleParasites & vectors2018
Glutathione S-transferases play a role in the detoxification of flumethrin and chlorpyrifos in Haemaphysalis longicornis.
Article in Parasites & vectors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
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- The pan-genome of Spodoptera frugiperda provides new insights into genome evolution and horizontal gene transfer.Communications biology · 2025Article
- A review of acaricides and their resistance mechanisms in hard ticks and control alternatives with synergistic agents.Acta tropica · 2025Review
- Egg Protein Compositions over Embryonic Development inAnimals : an open access journal from MDPI · 2024Article
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- In Vivo Characterization of the Anti-Glutathione S-Transferase Antibody Using an In Vitro Mite Feeding Model.Vaccines · 2024Article
- In Silico Exploration and Experimental Validation ofLife (Basel, Switzerland) · 2023Article
- Xenobiotic-Metabolizing Enzymes in Trematodes.Biomedicines · 2022Review
- Glutathione S-Transferase May Contribute to the Detoxification of (S)-(-)-Palasonin inInsects · 2022Article
- Observing How Glutathione and S-Hexyl Glutathione Bind to Glutathione S-Transferase fromInternational journal of molecular sciences · 2022Article
- Evaluation of acaricidal resistance status of Rhipicephalus microplus ticks from the hilly state (Uttarakhand) of India and evaluation of efficacy of a natural formulation for the management of resistant ticks.Experimental & applied acarology · 2021Article
- Identification and Characterization of Immunodominant Proteins from Tick Tissue Extracts Inducing a Protective Immune Response againstVaccines · 2021Article
- Determination of resistance status to amitraz in the cattle tick Rhipicephalus (Boophilus) microplus from Luzon, Philippines, through bioassay and molecular analysis.Experimental & applied acarology · 2021Article
- Interactive Gene Expression BetweenFrontiers in physiology · 2021Article
- DNA Methyltransferases Contribute to Cold Tolerance in TicksFrontiers in veterinary science · 2021Article
- Association of Genetic Polymorphisms inIranian journal of public health · 2020Article
- Expression analysis of glutathione S-transferases and ferritins during the embryogenesis of the tickHeliyon · 2020Article
- Comparative Proteomic Analysis ofFrontiers in cellular and infection microbiology · 2020Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundHaemaphysalis longicornis is a tick of importance to health, as it serves as a vector of several pathogens, including Theileria orientalis, Babesia ovata, Rickettsia japonica and the severe fever with thrombocytopenia syndrome virus (SFTSV). Presently, the major method of control for this tick is the use of chemical acaricides. The glutathione S-transferase (GST) system is one mechanism through which the tick metabolizes these acaricides. Two GSTs from H. longicornis (HlGST and HlGST2) have been previously identified.
resultsEnzyme kinetic studies were performed to determine the interaction of acaricides with recombinant H. longicornis GSTs. Recombinant HlGST activity was inhibited by flumethrin and cypermethrin, while recombinant HlGST2 activity was inhibited by chlorpyrifos and cypermethrin. Using real-time RT-PCR, the upregulation of the HlGST gene was observed upon exposure to sublethal doses of flumethrin, while the HlGST2 gene was upregulated when exposed to sublethal doses of chlorpyrifos. Sex and strain dependencies in the induction of GST gene expression by flumethrin were also observed. Knockdown of the HlGST gene resulted in the increased susceptibility of larvae and adult male ticks to sublethal doses of flumethrin and the susceptibility of larvae against sublethal doses of chlorpyrifos was increased upon knockdown of HlGST2.
conclusionsHlGST could be vital for the metabolism of flumethrin in larvae and adult male ticks, while HlGST2 is important in the detoxification of chlorpyrifos in larval ticks.
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