ArticleBreast cancer research : BCR2018
Volumetric breast density and risk of advanced cancers after a negative screening episode: a cohort study.
Article in Breast cancer research : BCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis.Breast (Edinburgh, Scotland) · 2022Pooled it
- Budget impact analysis of introducing digital breast tomosynthesis in breast cancer screening in Italy.La Radiologia medica · 2024Article
- Organizational impact of systemic implementation of digital breast tomosynthesis as a primary test for breast cancer screening in Italy.La Radiologia medica · 2024Article
- Multi-vendor robustness analysis of a commercial artificial intelligence system for breast cancer detection.Journal of medical imaging (Bellingham, Wash.) · 2023Article
- Cumulative Advanced Breast Cancer Risk Prediction Model Developed in a Screening Mammography Population.Journal of the National Cancer Institute · 2022Article
- Validation of a new fully automated software for 2D digital mammographic breast density evaluation in predicting breast cancer risk.Scientific reports · 2021Article
- Quantitative breast density analysis to predict interval and node-positive cancers in pursuit of improved screening protocols: a case-control study.British journal of cancer · 2021Article
- Advanced Breast Cancer Definitions by Staging System Examined in the Breast Cancer Surveillance Consortium.Journal of the National Cancer Institute · 2021Article
- The clinical impact of MRI screening for BRCA mutation carriers: the first report in Japan.Breast cancer (Tokyo, Japan) · 2019Article
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9 authors.
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Abstract
backgroundWe evaluated the association between volumetric breast density (BD) and risk of advanced cancers after a negative screening episode.
methodsA cohort of 16,752 women aged 49-54 years at their first screening mammography in the Florence screening programme was followed for breast cancer (BC) incidence until the second screening round. Volumetric BD was measured using fully automated software. The cumulative incidence of advanced cancer after a negative screening episode (including stage II or more severe cancer during the screening interval - on average 28 months - and at the subsequent round) was calculated separately for Volpara density grade (VDG) categories.
resultsBC incidence gradually increased with the increas in BD: 3.7‰, 5.1‰, 5.4‰ and 9.1‰ in the VDG categories 1-4, respectively (p trend < 0.001). The risk of advanced cancers after a negative screening episode was 1.0‰, 1.3‰, 1.1‰, and 4.2‰ (p trend = 0.003). The highest BD category, compared with the other three together, has double the invasive BC risk (RR = 2.0; 95% CI 1.5-2.8) and almost fourfold risk of advanced cancer (RR = 3.8; 95% CI 1.8-8.0).
conclusionBD has a strong impact on the risk of advanced cancers after a negative screening episode, the best early surrogate of BC mortality. Therefore, our results suggest that screening effectiveness is quite different among BD categories.
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