ArticleGenomics2019
Comparative transcriptomics of limb regeneration: Identification of conserved expression changes among three species of Ambystoma.
Article in Genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum).Advanced biology · 2025Article
- Antibacterial Activity of AXOTL-13, a Novel Peptide Identified from the Transcriptome of the SalamanderPharmaceutics · 2024Article
- ExpressAnalyst: A unified platform for RNA-sequencing analysis in non-model species.Nature communications · 2023Article
- Unravelling the limb regeneration mechanisms of Polypedates maculatus, a sub-tropical frog, by transcriptomics.BMC genomics · 2023Article
- Now that We Got There, What Next?Methods in molecular biology (Clifton, N.J.) · 2023Article
- Large-scale variation in single nucleotide polymorphism density within the laboratory axolotl (Ambystoma mexicanum).Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Towards comparative analyses of salamander limb regeneration.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2021Review
- Review
- Salamanders: The molecular basis of tissue regeneration and its relevance to human disease.Current topics in developmental biology · 2021Review
- Divergent Influenza-Like Viruses of Amphibians and Fish Support an Ancient Evolutionary Association.Viruses · 2020Article
- Article
- Integrative Analysis of Axolotl Gene Expression Data from Regenerative and Wound Healing Limb Tissues.Scientific reports · 2019Article
- HDAC Regulates Transcription at the Outset of Axolotl Tail Regeneration.Scientific reports · 2019Article
- The First Transcriptome Assembly of Yenyuan Stream Salamander (International journal of molecular sciences · 2019Article
- Regenerative Models for the Integration and Regeneration of Head Skeletal Tissues.International journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Transcriptome studies are revealing the complex gene expression basis of limb regeneration in the primary salamander model - Ambystoma mexicanum (axolotl). To better understand this complexity, there is need to extend analyses to additional salamander species. Using microarray and RNA-Seq, we performed a comparative transcriptomic study using A. mexicanum and two other ambystomatid salamanders: A. andersoni, and A. maculatum. Salamanders were administered forelimb amputations and RNA was isolated and analyzed to identify 405 non-redundant genes that were commonly, differentially expressed 24 h post amputation. Many of the upregulated genes are predicted to function in wound healing and developmental processes, while many of the downregulated genes are typically expressed in muscle. The conserved transcriptional changes identified in this study provide a high-confidence dataset for identifying factors that simultaneous orchestrate wound healing and regeneration processes in response to injury, and more generally for identifying genes that are essential for salamander limb regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.