ArticlePloS one2018
Lung injury does not aggravate mechanical ventilation-induced early cerebral inflammation or apoptosis in an animal model.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Systematic review of cognitive impairment and brain insult after mechanical ventilation.Critical care (London, England) · 2021Pooled it
- Sedation as an Immunomodulator of Inflammatory Responses in the Lung-Brain Axis of ARDS.International journal of molecular sciences · 2026Review
- Organ crosstalk: brain-lung interaction.Frontiers in medicine · 2025Review
- Assessment of Autoregulation of the Cerebral Circulation during Acute Lung Injury in a Neonatal Porcine Model.Children (Basel, Switzerland) · 2024Article
- Effect of a physician-nurse integrated lung protection care model in neurocritical patients.Preventive medicine reports · 2024Article
- Phrenic nerve stimulation mitigates hippocampal and brainstem inflammation in an ARDS model.Frontiers in physiology · 2023Article
- Diaphragm Neurostimulation Mitigates Ventilation-Associated Brain Injury in a Preclinical Acute Respiratory Distress Syndrome Model.Critical care explorations · 2022Article
- ARDS associated acute brain injury: from the lung to the brain.European journal of medical research · 2022Review
- Brain-lung interaction: a vicious cycle in traumatic brain injury.Acute and critical care · 2022Article
- Hyaluronic acid plasma levels during highPeerJ · 2022Article
- Transvenous Diaphragm Neurostimulation Mitigates Ventilation-associated Brain Injury.American journal of respiratory and critical care medicine · 2021Article
- Pathophysiology of Brain Injury and Neurological Outcome in Acute Respiratory Distress Syndrome: A Scoping Review of Preclinical to Clinical Studies.Neurocritical care · 2021Article
- Influence of rosuvastatin treatment on cerebral inflammation and nitro-oxidative stress in experimental lung injury in pigs.BMC anesthesiology · 2021Article
- Mechanical ventilation and neurocritical patients: is there a role for anti-neuroinflammatory therapies?Critical care (London, England) · 2020Article
- Article
- Harmful effects of mechanical ventilation on neurocognitive functions.Critical care (London, England) · 2019Article
- Random allogeneic blood transfusion in pigs: characterisation of a novel experimental model.PeerJ · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe acute respiratory distress syndrome is not only associated with a high mortality, but also goes along with cognitive impairment in survivors. The cause for this cognitive impairment is still not clear. One possible mechanism could be cerebral inflammation as result of a "lung-brain-crosstalk". Even mechanical ventilation itself can induce cerebral inflammation. We hypothesized, that an acute lung injury aggravates the cerebral inflammation induced by mechanical ventilation itself and leads to neuronal damage.
methodsAfter approval of the institutional and state animal care committee 20 pigs were randomized to one of three groups: lung injury by central venous injection of oleic acid (n = 8), lung injury by bronchoalveolar lavage in combination with one hour of injurious ventilation (n = 8) or control (n = 6). Brain tissue of four native animals from a different study served as native group. For six hours all animals were ventilated with a tidal volume of 7 ml kg-1 and a scheme for positive end-expiratory pressure and inspired oxygen fraction, which was adapted from the ARDS network tables. Afterwards the animals were killed and the brains were harvested for histological (number of neurons and microglia) and molecular biologic (TNFalpha, IL-1beta, and IL-6) examinations.
resultsThere was no difference in the number of neurons or microglia cells between the groups. TNFalpha was significantly higher in all groups compared to native (p < 0.05), IL-6 was only increased in the lavage group compared to native (p < 0.05), IL-1beta showed no difference between the groups. DISCUSSION: With our data we can confirm earlier results, that mechanical ventilation itself seems to trigger cerebral inflammation. This is not aggravated by acute lung injury, at least not within the first 6 hours after onset. Nevertheless, it seems too early to dismiss the idea of lung-injury induced cerebral inflammation, as 6 hours might be just not enough time to see any profound effect.
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