Evidence map›Paper›PMID 30091759›Full record

ArticleChemical communications (Cambridge, England)2018

Real-time tracking of single-molecule collagenase on native collagen and partially structured collagen-mimic substrates.

James Froberg, Woo-Sik Choi, Abbas Sedigh, Tayebeh Anajafi, Jasmin Farmakes, Zhongyu Yang, Sanku Mallik, D K Srivastava, Yongki Choi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

James FrobergDepartment of Physics, North Dakota State University, Fargo, North Dakota 58108, USA. yongki.choi@ndsu.edu.
Woo-Sik Choi
Abbas Sedigh
Tayebeh Anajafi
Jasmin Farmakes
Zhongyu Yang
Sanku Mallik
D K Srivastava
Yongki Choi
Dakota State University · US

Funding

Pilot Projects: Core DP30GM103332 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI SIBI, MUKUND P. · 2012 to 2016
$4.9M
Developing a hybrid biomolecule nano-circuit approach for observing and manipulating single protein dynamicsR15GM122063 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI CHOI, YONGKI · 2016 to 2016
$424k
Isozyme Selectivity among Triple Helix Cleaving MetalloproteinasesR15GM110637 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI SRIVASTAVA, D. K · 2014 to 2014
$347k
NIGMS NIH HHS P30 GM103332NIGMS NIH HHS R15 GM110637NIGMS NIH HHS R15 GM122063
6 · The paper itself

Abstract

The dynamic interactions of an individual matrix metalloproteinase-1 were imaged and monitored in the presence of either triple-helical or non-triple-helical, partially structured collagen-mimic substrates. The enzyme exhibited ten-fold increased catalytic turnover rates with the structurally modified substrate by skipping the triple-helix unwinding step during the catalytic pathway.

Indexed as

Molecular MimicryCatalysisCollagenCrystallography, X-RayKineticsMatrix Metalloproteinase 1Microscopy, Atomic ForceProtein ConformationSubstrate SpecificityCollagenMatrix Metalloproteinase 1

Identifiers

PMID30091759
PMCPMC6145137
OpenAlexW2883701460

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.