ArticlePhysiological measurement2018
Validation of x-ray fluorescence measurements of metals in toenail clippings against inductively coupled plasma mass spectrometry in a Nigerian population<sup/>.
Article in Physiological measurement, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Comparison between inductively coupled plasma-mass spectrometry and benchtop X-ray fluorescence performance for trace elemental exposure in rat tissues.Journal of trace elements and minerals · 2025Article
- Elevated Metal Levels in U.S. Honeys: Is There a Concern for Human Health?Biological trace element research · 2025Article
- Ways to Measure Metals: From ICP-MS to XRF.Current environmental health reports · 2025Review
- Portable x-ray fluorescence for bone lead measurement: Current approaches and future directions.Current environmental health reports · 2024Review
- Benchtop x-ray fluorescence to quantify elemental content in nails non-destructively.The Science of the total environment · 2024Article
- Quantitative analysis of human hairs and nails.Biophysical reviews · 2023Review
- Validation of in vivo toenail measurements of manganese and mercury using a portable X-ray fluorescence device.Journal of exposure science & environmental epidemiology · 2022Article
- Study Protocol: Interactive Dynamics of Coral Reef Fisheries and the Nutrition Transition in Kiribati.Frontiers in public health · 2022Article
- Portable X-ray Fluorescence as a Rapid Determination Tool to Detect Parts per Million Levels of Ni, Zn, As, Se, and Pb in Human Toenails: A South India Case Study.Environmental science & technology · 2021Article
- Feasibility of Lead Exposure Assessment in Blood Spots using Energy-Dispersive X-ray Fluorescence.Environmental science & technology · 2021Article
- Toenail Metal Exposures in Fishermen from Bodo City, Nigeria.Bulletin of environmental contamination and toxicology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveMetal exposures have been linked with many adverse health outcomes affecting nearly every system in the body. Exposure to metals has been tracked primarily using blood. Blood metal concentrations have drawbacks as biomarkers stemming from the metals' short biologic half-lives, shipping and storage requirements, and invasive collection procedures. Toenails, which capture a longer exposure period, can be collected non-invasively and stored at room temperature, and can be more feasible and cost-effective for large-scale population studies. APPROACH: Inductively coupled plasma mass spectrometry (ICP-MS) has been used for analysis of toenail metal concentrations, but x-ray fluorescence (XRF) has many advantages in versatility and cost effectiveness over these analyses. This study compared toenail concentrations of manganese (Mn) and lead (Pb) measured with XRF against ICP-MS, in samples collected from 20 adults in Nigeria. To do this we developed a novel calibration method that corrects XRF measurements for toenail weight and thickness to reduce the variability in XRF measurements of toenail clippings. MAIN
resultsWe found a high correlation (R = 0.91) between toenail manganese metal measurements made with XRF and ICP-MS and a correlation of (R = 0.32) between toenail lead XRF and ICP-MS with over half of the lead results below the detection limit of the instrumentation. SIGNIFICANCE: XRF can be used effectively to quantify metals at the part per million level or lower depending on the XRF equipment used in the measurements.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.