ArticleeLife2018
Age-dependent dormant resident progenitors are stimulated by injury to regenerate Purkinje neurons.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Multi-omics characterization of radiation-induced cerebellar remodeling and tumorigenic transcriptional programs.Neoplasia (New York, N.Y.) · 2026Article
- Clonal embeddings allow exploratory analysis of lineage-resolved single-cell data.bioRxiv : the preprint server for biology · 2026Article
- Ageing versus developmental silencing: Answers from the epigenome.The FEBS journal · 2025Review
- Article
- Conference Report: Cerebellar Development and Disease at Single-Cell Resolution.Cerebellum (London, England) · 2025Article
- Blueprints for healing: central nervous system regeneration in zebrafish and neonatal mice.BMC biology · 2025Review
- Age-dependent regenerative mechanisms in the brain.Biochemical Society transactions · 2024Review
- Cell specificity of Manganese-enhanced MRI signal in the cerebellum.NeuroImage · 2023Article
- Neonatal subarachnoid hemorrhage disrupts multiple aspects of cerebellar development.Frontiers in molecular neuroscience · 2023Article
- Cerebellum lineage allocation, morphogenesis and repair: impact of interplay amongst cells.Development (Cambridge, England) · 2022Review
- Associations between genetic loci, environment factors and mental disorders: a genome-wide survival analysis using the UK Biobank data.Translational psychiatry · 2022Article
- Injury-induced ASCL1 expression orchestrates a transitory cell state required for repair of the neonatal cerebellum.Science advances · 2021Article
- Deconstructing cerebellar development cell by cell.PLoS genetics · 2020Review
- YAP1 is involved in replenishment of granule cell precursors following injury to the neonatal cerebellum.Developmental biology · 2019Article
- Emerging connections between cerebellar development, behaviour and complex brain disorders.Nature reviews. Neuroscience · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Outside of the neurogenic niches of the brain, postmitotic neurons have not been found to undergo efficient regeneration. We demonstrate that mouse Purkinje cells (PCs), which are born at midgestation and are crucial for development and function of cerebellar circuits, are rapidly and fully regenerated following their ablation at birth. New PCs are produced from immature FOXP2+ Purkinje cell precursors (iPCs) that are able to enter the cell cycle and support normal cerebellum development. The number of iPCs and their regenerative capacity, however, diminish soon after birth and consequently PCs are poorly replenished when ablated at postnatal day five. Nevertheless, the PC-depleted cerebella reach a normal size by increasing cell size, but scaling of neuron types is disrupted and cerebellar function is impaired. Our findings provide a new paradigm in the field of neuron regeneration by identifying a population of immature neurons that buffers against perinatal brain injury in a stage-dependent process.
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